Postdoctoral Fellow: Cryo-EM & Cytoskeletal Remodeling

Francis Crick Institute; Greater London; On-site; GBP 43,000 - 52,000; Full time

Job summary

The Francis Crick Institute invites applications for a Postdoctoral Fellow in Structural Biology and Cytoskeletal Remodeling (Chaaban Lab). The role focuses on cryo-EM, protein biochemistry and fluorescence microscopy to study microtubule remodeling during cell division.

You will develop and lead a research project, generate recombinant proteins, and integrate structural findings with biochemical and imaging experiments.

Qualifications

• PhD (or PhD on submission) in structural biology, biochemistry, molecular biology, biophysics, or related field.
• Experimental expertise in protein biochemistry and cryo-EM, including sample preparation and data collection.
• Strong interest in combining cryo-EM with quantitative fluorescence microscopy.
• Experience designing experiments, applying statistics, interpreting data, and troubleshooting research problems.
• Evidence of scientific initiative and ability to develop research questions independently.

Responsibilities

• Developing and leading a research project investigating the molecular mechanisms of cytoskeletal remodeling.
• Producing and characterizing recombinant proteins and protein complexes, and establishing assays to measure their interactions and activity.
• Using cryo-EM and computational image analysis to investigate the organisation and conformational states of molecular assemblies.
• Integrating structural findings with biochemical and fluorescence microscopy experiments to test mechanistic hypotheses.
• Analysing and documenting experiments rigorously, presenting findings at scientific meetings, and contributing to manuscripts and publications.

Skills

Experimental design

Data analysis

Troubleshooting

Scientific initiative

Education

PhD in structural biology/biochemistry/molecular biology/biophysics

Tools

Cryo-EM

Computational image analysis

Job description

The Francis Crick Institute invites applications for a Postdoctoral Fellow in Structural Biology and Cytoskeletal Remodeling (Chaaban Lab). The role focuses on cryo-EM, protein biochemistry and fluorescence microscopy to study microtubule remodeling during cell division.

You will develop and lead a research project, generate recombinant proteins, and integrate structural findings with biochemical and imaging experiments.