Postdoc Scientist - Hematopoietic & T-Cell Development

The University of Manchester; Manchester; On-site; GBP 36,000 - 48,000; Full time

Job summary

The University of Manchester invites applications for a Postdoctoral Scientist in the Stem Cell Biology group to investigate how human haemogenic endothelium gives rise to pro-T-cell progenitors and how these progenitors acquire the capacity to generate αβ and γδ T cells. The project aims to improve cellular immunotherapy and transplantation through mechanistic studies and high-throughput screening.

You will work within a multidisciplinary team, generating hypotheses and testing them using human

Qualifications

• PhD in stem cell biology, developmental haematology, immunology, cancer biology, or related discipline.
• Substantial experience in mammalian cell culture and molecular or cellular experimentation.
• Strong skills in experimental design, quantitative data interpretation and scientific communication.
• Experience in human pluripotent stem cells, developmental haematopoiesis, T-cell biology, flow cytometry, high-throughput screening, genome engineering, single-cell approaches, computational analysis or in vivo models would be advantageous.

Responsibilities

• Establish and use experimental models of human blood and immune development to investigate pro-T-cell progenitors.
• Generate and test mechanistic hypotheses about early human T-cell development.
• Integrate cellular, molecular and functional studies with high-throughput compound screening to identify pathways and interventions that enhance T-cell specification.
• Work within a multidisciplinary team.

Skills

Mammalian cell culture

Quantitative data interpretation

Experimental design

Computational analysis

Single-cell approaches

Scientific communication

Pro-T-cell biology

Education

PhD in stem cell biology / related discipline

Tools

Flow cytometry

High-throughput screening

Job description

The University of Manchester invites applications for a Postdoctoral Scientist in the Stem Cell Biology group to investigate how human haemogenic endothelium gives rise to pro-T-cell progenitors and how these progenitors acquire the capacity to generate αβ and γδ T cells. The project aims to improve cellular immunotherapy and transplantation through mechanistic studies and high-throughput screening.

You will work within a multidisciplinary team, generating hypotheses and testing them using human