PhD Studentship: New Single-Molecule Tools to Study Self-Assembly

University of Warwick; Warwick; On-site; GBP 18,000 - 22,000; Full time

Benefits offered by this job

UKRI-funded stipend

Tuition fees covered

Job summary

University of Warwick offers a 3.5-year PhD studentship in the Chemistry department to develop the next generation of a spatial spectral microscope for observing single molecules as they assemble into complexes. The project includes hands-on instrument design, electronics, and programming for automation, plus imaging experiments and data analysis.

You will join a new Warwick Chemistry group with close collaboration with Göttingen, Geneva and Durham, contributing to the understanding of early

Qualifications

• Applicants should hold, or expect to obtain, a strong undergraduate degree in Chemistry, Physics or a related discipline by the start of the project.
• You should enjoy building things, physical chemistry, coding, and taking apparatus apart.

Responsibilities

• Build a new single-molecule microscope and learn instrument design, electronics and programming for automation.
• Design and implement single-molecule imaging experiments and learn data analysis and numerical simulation.
• Study imaging of self-assembly in model systems and cells, including cell culture and biophysical sample preparation.

Skills

Building things

Physical chemistry

Coding

Apparatus disassembly

Education

Undergraduate degree in Chemistry, Physics or related discipline

Job description

Supervisor: Joe Beckwith, [e-mail]. Please contact for informal enquiries.

Research Summary

Proteins rarely work alone. They assemble into complexes, and the order in which they come together can decide whether a cell sends a signal or forms a toxic aggregate. That order is almost impossible to see with bulk methods, which average over millions of molecules. We have developed a microscope (preprint) that records both the position and the spectral fingerprint of individual molecules, letting us tell many molecules apart at once. In this project, you'll build the next generation of this instrument and use it to watch complexes assemble, one molecule at a time.

This will involve:

• Building a new single-molecule microscope.
  • You’ll learn instrument design, electronics and programming for instrument automation as well as mechanical construction.
• Designing and implementing single-molecule imaging experiments.
  • You will learn data (and image) analysis, numerical simulation, and chemical dynamics analyses.
• Imaging self-assembly in model systems and cells.
  • You will learn cell culture, as well as biophysical sample preparation.

This next generation instrument will then be applied to the earliest stages of T-cell activation: a three-part protein complex assembly that governs how our adaptive immune system responds to threats.

Why this group?

You’ll be the first PhD student in a newly established group in Warwick Chemistry. That means hands‑on supervision and a real say in how the lab and its work takes shape. Joe recently co‑developed the spatial spectral microscope this project builds on, work that is now the subject of a patent application. For more information on the lab, please see jsbeckwith-lab.com.

The group sits at the interface of physical chemistry and biophysics. Alongside immune signalling, we use photothermal and single‑molecule methods to study how nanoparticles form. You’ll also benefit from our collaborations with groups in Göttingen, Geneva and Durham and links outside academia, giving you a wide network and experience.

Funding Notes

This studentship (3.5 years) is funded by UKRI, covering a stipend and tuition fees, for a UK student, at the UKRI rate. Please contact Joe for further details.

Start Date:October 2027

Application Deadline: 31 January 2027

Eligibility

We welcome applications from all suitably qualified candidates, and particularly encourage applications from under‑represented groups. We are seeking someone who enjoys building things, physical chemistry, coding, and taking apparatus apart. Applicants should hold, or expect to obtain, a strong undergraduate degree in Chemistry, Physics or a related discipline by the start of the project.