Membrane Protein Folding

Aston University; Birmingham; On-site; GBP 34,000 - 42,000; Full time

Benefits offered by this job

Training and development

30 days leave + bank holidays

On-site gym and staff perks

Job summary

Aston University invites applications for a Postdoctoral Research Associate to join a newly funded BBSRC Pioneer Award project on mammalian membrane protein folding and assembly using dynamic mass photometry. The role is fixed-term for 22 months and housed within the Aston Institute for Membrane Excellence (AIME).

The successful candidate will combine cell-free methods to track membrane protein synthesis on ribosomes and use DMP to visualise insertion, folding and assembly in artificial lipid

Qualifications

• Strong background in membrane biology, lipid biochemistry or microscopy/image analysis.
• PhD completed or near-completion in a relevant field.
• Ability to drive research projects independently on a day-to-day basis.

Responsibilities

• Track mammalian membrane protein synthesis on ribosomes using cell-free methods.
• Use dynamic mass photometry to visualise protein insertion, folding and assembly in artificial lipid bilayers.
• Collaborate across membrane biology, biochemistry and imaging; rapid learning of new techniques.

Skills

Membrane biology

Lipid biochemistry

Microscopy

Image analysis

DMP techniques

Education

PhD in related field

Tools

ImageJ

Python

Job description

Location: Aston University Main Campus

Grade: Grade 08

ContractType: Fixed Term(22 months)

Basis: Full Time

ClosingDate: 23.59 hours GMT on Monday 09 November 2026

InterviewDate: Tuesday 01 December 2026

Reference: 1648-26

ReleaseDate: Monday 12 October 2026

We are seeking a highly motivated Postdoctoral Research Associate to join a newly funded BBSRC Pioneer Award exploring the fundamental principles that govern mammalian membrane protein folding and assembly during biogenesis using dynamic mass photometry (DMP), a label-free single particle tracking technique.

This position is embedded within the vibrant, collaborative environment of the Aston Institute for Membrane Excellence (AIME). AIME is a first-of-its-kind institute that synergistically combines world-leading expertise in membrane biology and novel polymer chemistries.

In this highly collaborative project, the successful candidate will combine cell-free methodologies to track mammalian membrane protein synthesis on ribosomes, using DMP to visualise membrane protein insertion, folding, and assembly within artificial lipid bilayers which mimic mammalian lipid composition.

We are looking for candidates with a strong background in membrane biology protein and lipid biochemistry, or microscopy and image analysis, and a passion for applying multidisciplinary methods to understand de novo membrane protein folding. The ability to rapidly learn new techniques is highly desirable, and enthusiasm for working across disciplinary boundaries is essential. Full training will be provided where needed. Prior experience in independently driving research projects on a day‑to‑day basis is required.

Applicants who have recently submitted their PhD and are awaiting award are welcome to apply.

This is a 22‑month fixed‑term post, commencing in January 2027.

What we offer:

• Aston University is a dynamic and vibrant campus located within Birmingham city centre, which has excellent transport links via bus or train.
• Excellent training and development opportunities.
• A generous annual leave scheme with 30 days bookable leave and a further 13 days bank holiday and University Closure days.
• Everyday discounts to a number of activities and retailers
• Great family friendly policies
• On site gym and pool with discounted staff membership available
• Further information on our Benefits and Rewards can be found here

This role is likely to qualify for endorsement under the Endorsed Funder route of the Global Talent visa. This visa is for talented or promising individuals in academia or research in fields such as science, engineering, medicine, social sciences, or humanities.

The University celebrates the rights of freedom of speech and academic freedom and is committed to maintaining and protecting these rights within the law. An offer to work at Aston University will never be denied on the basis of an individual’s lawful expression of their beliefs, ideas or opinions.

Aston University is an equal opportunities employer and welcomes applications from all sections of the community. It promotes equality and diversity in all aspects of its work. We strive to have robust inclusivity strategies in place, to encourage colleagues to have the confidence and freedom to be themselves in the workplace. For more information, visit: https://www2.aston.ac.uk/about/inclusive-aston

Guidance on AI-Assisted Applications

While we cannot prevent applicants from using AI tools to support their application, we ask that all submissions reflect your own experience, achievements, and motivations. We want to understand what you personally bring to the role, so please ensure your application represents your own voice and capabilities.

We recognise the value of flexible working. Please contact the recruiting manager to discuss what flexible working options are available for particular roles.

If you require the job details document or an application form in an alternative format please contact the recruitment team at [e-mail]