Post Doctoral Research Associate: Custom Optical Microscopy Development (Fixed Term)

Economics Network; Cambridge; Remote; GBP 33,000 - 46,000; Full time

Job summary

The University of Cambridge invites applications for a Postdoctoral Research Associate (PDRA) to develop custom optics integrated with microfluidic ultra-high-throughput screening (uHTS) for label-free screening of phase separation in de novo designed inorganic–protein hybrids. The role sits in the Knowles group, Dept.

of Chemistry, with ARIA-supported international collaboration. Responsibilities include building, aligning and maintaining polarization and fluorescence microscope systems,

Qualifications

• Experience building a bespoke optical microscope from components and describing personal contributions.
• PhD in Optical Engineering, Physics, Chemistry, Materials Science, Minerals or related field required or underway.

Responsibilities

• Design, assemble, and maintain microscopes integrating polarization-resolved and fluorescence optics.
• Collaborate with consortium partners to extend uHTS to new inorganic-protein composites.
• Supervise PhD and Master’s students and maintain group instruments.

Skills

Optical microscope design

Polarisation optics

Fluorescence optics

Microfluidics

Education

PhD in Optical Engineering or related field

Tools

PhaseScan

Microscope alignment

Job description

Fixed-term: The funds for this post are available for 18 months in the first instance, if project milestone targets are met at 18 months, a further 18 months of funding will be allocated.

Applications are invited for a Postdoctoral Research Associate (PDRA) to develop custom optics integrated with microfluidic ultra-high-throughput screening (uHTS) for label free screening of phase separation in de novo designed inorganic-protein hybrid materials. Techniques developed include polarised optical microscopy (POM), fluorescence microscopy, and darkfield microscopy, coupled to droplet microfluidics for screening for libraries of 10K to >1M samples. Scientific objectives are to map the phase space of ordered inorganic hybrid materials. Screens will explore the multidimensional parameter sampling of reaction conditions and libraries of de novo inorganic-templating interfaces. The PDRA will be hosted in the group of Professor Knowles in the Department of Chemistry at Cambridge University, funded by an Advanced Research + Invention Agency (ARIA) international consortium.

The PDRA will be responsible for designing, assembling, and maintaining microscopes which integrate polarisation-resolved and fluorescence optics with existing custom microfluidic droplet screening platforms including PhaseScan and cell free expression.

Training in microfluidics will be provided. The Knowles group brings expertise in droplet-based screening, soft matter physics, biophysics, and phase separation, and the post holder is not expected to arrive with that background. Consortium partners bring expertise in de novo protein design and high-throughput inorganic synthesis. Collaborating closely with these partners, the PDRA will design, build, and utilise systems to enable uHTS to be extended to de novo designed inorganic-protein composites, identifying and optimising conditions which produce functional hybrid materials.

Further duties include contributing to the supervision of PhD and Master's students and assisting with the maintenance of the group's custom instruments.

Candidate requirements:

• Demonstrated experience of building a bespoke optical microscope from individual components, including optical design, sourcing, assembly, alignment and characterisation of performance. Applicants must describe at least one instrument they have built and their specific personal contribution to it.
• A PhD (or be about to obtain) in Optical Engineering, Physics, Chemistry, Materials Science, Mineralogy, or a related discipline.

The ideal candidate will possess:

• Experience studying the synthesis and/or characterisation of crystalline inorganic materials.
• A sound understanding of polarisation optics (e.g. Jones/Mueller calculus) and practical experience of polariser/analyser alignment.
• Knowledge of fluorescence optics, including excitation/emission filtering and the selection of dichroics and filter sets.

For queries relating to your application or the application process, please contact Echo Wu via email on [e-mail].

The Department holds an Athena SWAN silver award for women in Science, Technology, Engineering, Mathematics, and Medicine.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

£33,002 to £46,049 per annum