PhD: Sodium-Driven Eukaryotic DNA Replication Research

Laplace Expert Ltd; York and North Yorkshire; Hybrid; GBP 18,000 - 21,000; Full time

Job summary

University of York invites applications for a PhD project on sodium regulation of eukaryotic DNA replication. The project will investigate how sodium-rich cellular environments alter replication machinery using DNA fibre combing, iPOND, proteomics, OK-seq and live-cell imaging.

York bioscience doctoral training partnership supports this four-year studentship with a scholarship funding type. Start date is September 20, 2027, with a focus on cutting-edge replication stress research.

Qualifications

• Requires PhD-level research experience in biology/biophysics.
• Experience with DNA replication assays and single-molecule techniques is preferred.
• Familiarity with high-throughput sequencing and proteomics workflows beneficial.

Responsibilities

• Conduct and contribute to research on sodium regulation of eukaryotic DNA replication.
• Apply DNA fibre combing, iPOND, proteomics and OK-seq to study replication stress.
• Perform live-cell imaging and single-molecule biophysics experiments.

Skills

DNA fibre combing

iPOND

proteomics

OK-seq

live-cell imaging

single-molecule biophysics

Education

PhD

Job description

University of York invites applications for a PhD project on sodium regulation of eukaryotic DNA replication. The project will investigate how sodium-rich cellular environments alter replication machinery using DNA fibre combing, iPOND, proteomics, OK-seq and live-cell imaging.

York bioscience doctoral training partnership supports this four-year studentship with a scholarship funding type. Start date is September 20, 2027, with a focus on cutting-edge replication stress research.