PhD: Sodium Regulation of Eukaryotic DNA Replication

Laplace Apply; York and North Yorkshire; Hybrid; GBP 18,000 - 21,000; Full time

Job summary

University of York invites applications for a PhD project on sodium regulation of eukaryotic DNA replication. The project will investigate how sodium-rich cellular environments alter replication machinery using DNA fibre combing, iPOND, proteomics, OK-seq and live-cell imaging.

York bioscience doctoral training partnership supports this four-year studentship with a scholarship funding type. Start date is September 20, 2027, with a focus on cutting-edge replication stress research.

Qualifications

• Requires PhD-level research experience in biology/biophysics.
• Experience with DNA replication assays and single-molecule techniques is preferred.
• Familiarity with high-throughput sequencing and proteomics workflows beneficial.

Responsibilities

• Conduct and contribute to research on sodium regulation of eukaryotic DNA replication.
• Apply DNA fibre combing, iPOND, proteomics and OK-seq to study replication stress.
• Perform live-cell imaging and single-molecule biophysics experiments.

Skills

DNA fibre combing

iPOND

proteomics

OK-seq

live-cell imaging

single-molecule biophysics

Education

PhD

Job description

PhD: Sodium Regulation of Eukaryotic DNA Replication

University of York

United Kingdom

2027-01-06 (date only; cutoff time not explicitly verified)

About This Opportunity

University of York offers phd: sodium regulation of eukaryotic dna replication in York. The specific focus is the university of york project tests how sodium-rich cellular environments alter the eukaryotic replication machinery.

The University of York project tests how sodium-rich cellular environments alter the eukaryotic replication machinery. Research combines renal and other mammalian cell systems with single-molecule DNA fibre analysis, active fork isolation and sequencing to investigate replication stress and genome instability. The advertised activities and techniques include DNA fibre combing, iPOND, proteomics, OK-seq, live-cell imaging, single-molecule biophysics.Who This Opportunity Is Best Suited For: Based on the documented research scope, this may particularly suit applicants from biological, biochemical, biophysical or related sciences with interest in replication stress.Potential Challenges / Who May Find It Less Suitable: Applicants requiring a UK student visa are explicitly ineligible for this York YBDTP project; competitive studentship.Overall Opportunity Assessment: The advertised work connects DNA fibre combing, iPOND, proteomics, OK-seq, live-cell imaging, single-molecule biophysics. Its distinguishing purpose is the University of York project tests how sodium-rich cellular environments alter the eukaryotic replication machinery. Applicants should assess the documented academic and practical constraints before proceeding.

DNA fibre combing iPOND proteomics OK-seq live-cell imaging single-molecule biophysics

Level PhD

Start Date Sep 20, 2027

Duration 4 years

Programme Yorkshire Bioscience Doctoral Training Partnership (YBDTP)

Organization Type University

Funding & Compensation

Amount Scholarship

Funding Type Scholarship

Requirements

Education

Experience

Technical Skills

DNA fibre combing iPOND proteomics OK-seq live-cell imaging single-molecule biophysics

General Skills

Languages

Students requiring a UK student visa are not eligible for this University of York YBDTP project.