Oxford CAR-T/TCR Scientist - Lab Lead

Northreach

Oxford

On-site

GBP 35,000 - 65,000

Full time

14 days+

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Benefits offered by this job

Collaborative scientific team

Opportunity for impactful work in immuno-oncology

Job summary

Northreach is seeking a skilled Scientist for a dynamic lab-based role focusing on immuno-oncology at our Oxford site. You will lead experimental design for CAR-T and TCR therapy, execute in vitro functional assays, and collaborate with diverse teams. Candidates must hold a PhD in a related discipline and have expertise in CAR-T/TCR development, along with strong skills in flow cytometry and assay development. Join us and contribute to groundbreaking advances in next-generation cell therapy innovation.

Qualifications

PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required.
Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy.
Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture.

Responsibilities

Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity.
Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering.
Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data.
Develop and validate ELISA and Western blot assays to support functional and mechanistic studies.
Collaborate closely with bioinformatics, translational, and cell engineering teams.