Scientist

Northreach; Oxford; On-site; GBP 35,000 - 65,000; Full time

Benefits offered by this job

Collaborative scientific team

Opportunity for impactful work in immuno-oncology

Job summary

Northreach is seeking a skilled Scientist for a dynamic lab-based role focusing on immuno-oncology at our Oxford site. You will lead experimental design for CAR-T and TCR therapy, execute in vitro functional assays, and collaborate with diverse teams. Candidates must hold a PhD in a related discipline and have expertise in CAR-T/TCR development, along with strong skills in flow cytometry and assay development. Join us and contribute to groundbreaking advances in next-generation cell therapy innovation.

Qualifications

• PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required.
• Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy.
• Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture.

Responsibilities

• Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity.
• Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering.
• Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data.
• Develop and validate ELISA and Western blot assays to support functional and mechanistic studies.
• Collaborate closely with bioinformatics, translational, and cell engineering teams.

Skills

Immunology

Molecular Biology

Cell Biology

CAR-T/TCR development

T cell engineering

Flow cytometry

ELISA

Western blot

Assay development

Education

PhD in Immunology, Molecular Biology, Cell Biology

Job description

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Base pay range

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We are seeking an exceptional Scientist with a passion for immuno-oncology and hands-on expertise in CAR-T and TCR cell therapy discovery and development. This is a dynamic, lab-based role based at our Oxford site, where you will lead experimental design, execute in vitro functional assays, and collaborate cross-functionally to advance innovative cell therapies toward the clinic.

This position offers an exciting opportunity to contribute directly to the design and optimisation of novel CAR-T constructs within a fast-paced, collaborative biotech environment.

Key Responsibilities:

• Lead the design, development, and execution of in vitro functional assays to evaluate CAR-T/TCR activity, including cytotoxicity, cytokine release, and target engagement.
• Develop, optimise, and troubleshoot protocols for CAR construct screening and primary T cell engineering.
• Design and perform multiparameter flow cytometry experiments; analyse and interpret complex immunophenotyping data.
• Develop and validate ELISA and Western blot assays to support functional and mechanistic studies.
• Generate actionable insights from experimental data to guide CAR/TCR construct selection and refinement.
• Collaborate closely with bioinformatics, translational, and cell engineering teams to integrate data and align project goals.
• Prepare scientific presentations, technical reports, and contribute to regulatory documentation as needed.
• Stay abreast of emerging trends in CAR-T/TCR research and immuno-oncology; implement innovative approaches in R&D.
• Mentor junior scientists and foster a culture of scientific rigor, curiosity, and innovation.

Qualifications:

• PhD in Immunology, Molecular Biology, Cell Biology, or related discipline is required for Scientist level (Master’s with significant biotech experience considered for Senior RA role).
• Hands-on expertise in CAR-T/TCR development, T cell engineering, or immune cell therapy.
• Strong practical knowledge of multiparameter flow cytometry, ELISA, Western blot, assay development, and primary immune cell culture.
• Proven ability to analyse complex datasets and extract meaningful biological insights.
• Excellent scientific communication skills, both written and verbal.
• Ability to work independently and collaboratively in a fast-paced, team-oriented environment.
• Must be able to work on-site at our Oxford facility.

Why Join Us?

• Contribute to groundbreaking advances in next-generation cell therapy innovation.
• Work within a mission-driven, supportive, and collaborative scientific team.
• Opportunity to make a tangible impact on the future of immuno-oncology therapies.

If you are passionate about driving CAR-T/TCR therapy development and thrive in a fast-moving, impactful environment, and are able to work at our Oxford site, we encourage you to apply.

Seniority level

• Seniority level

  Mid-Senior level

Employment type

• Employment type

  Full-time

Job function

• Job function

  Science

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