Mito Base Editor Scientist: Precision Editing Tools

Nuclear Inst; Cambridge, Manchester; On-site; GBP 21,000 - 28,000; Full time

Job summary

Nuclear Inst is seeking a trainee scientist to join the Minczuk lab at the Cambridge Institute for Medical Research as part of CoRE‑MitoGT. The project focuses on developing mitochondrial base editors with improved sequence specificity to target pathogenic mtDNA mutations.

You will work on editor design, testing in cellular models, and collaboration with Manchester groups to refine deaminase choices and DNA-binding domains.

Responsibilities

• Discover and benchmark sequence-selective deaminases.
• Engineer next-generation mitochondrial base editors with optimized domains and linkers.
• Develop quantitative screening and specificity assays for editor variants.
• Validate lead editors in disease-relevant cellular models and assess off-target effects.

Job description

Nuclear Inst is seeking a trainee scientist to join the Minczuk lab at the Cambridge Institute for Medical Research as part of CoRE‑MitoGT. The project focuses on developing mitochondrial base editors with improved sequence specificity to target pathogenic mtDNA mutations.

You will work on editor design, testing in cellular models, and collaboration with Manchester groups to refine deaminase choices and DNA-binding domains.