Eukaryotic Genome Engineer – Mammalian Editing Specialist

Cultivarium; Greater London; On-site; GBP 90,000 - 120,000; Full time

Benefits offered by this job

Annual leave and holidays

Private medical insurance

Pension contribution

Job summary

Cultivarium is seeking a scientist to engineer eukaryotic genomes with a focus on mammalian tissue culture. You will drive editing campaigns from design to verified edit, selecting nucleases and delivery methods, and confirming outcomes base by base.

This is an in-person role at our London, UK location. You will work across culture, delivery, screening, and verification, employing CRISPR tools and alternatives to optimise editing efficiency while minimising off-target effects.

Qualifications

• PhD in molecular or cell biology or related field.
• Demonstrated genome editing in mammalian cells from guide design through validation.

Responsibilities

• Design editing strategies and reagents for target loci and editing approaches.
• Build and QC editing reagents and deliver editing machinery.
• Maintain mammalian tissue culture across multiple cell types.
• Verify edits by NGS and other validation methods.
• Lead rigorous documentation and collaborative teamwork.

Skills

Genome editing

Mammalian tissue culture

CRISPR

NGS verification

ZFN/TALENs

Benchling

SnapGene

CRISPResso

Education

PhD in molecular or cell biology

Tools

Gibson Assembly

Golden Gate

PCR

Transfection

Electroporation

Job description

Cultivarium is seeking a scientist to engineer eukaryotic genomes with a focus on mammalian tissue culture. You will drive editing campaigns from design to verified edit, selecting nucleases and delivery methods, and confirming outcomes base by base.

This is an in-person role at our London, UK location. You will work across culture, delivery, screening, and verification, employing CRISPR tools and alternatives to optimise editing efficiency while minimising off-target effects.