Senior Antibody Characterisation Lead

Northreach; Greater London; On-site; GBP 90,000 - 120,000; Full time

Job summary

Northreach seeks a Principal Scientist to lead antibody characterisation and candidate-selection across its preclinical discovery efforts. The role blends deep biophysics with programme ownership and cross-functional collaboration with discovery, computational teams and external partners.

You will shape experimental strategies, assess large panels of antibody candidates, and drive decisions to progress molecules toward preclinical development.

Qualifications

• PhD or equivalent industry experience in biochemistry, biophysics or related discipline.
• Deep hands-on antibody characterisation experience including SPR/BLI.
• Strong track record in lead optimisation and candidate selection.
• Experience leading scientific projects across multidisciplinary teams.
• Proven ability to mentor scientists and manage external partners.

Responsibilities

• Lead antibody characterisation and optimisation across early-stage discovery and preclinical programmes.
• Define experimental strategies and progression criteria for screening and candidate selection.
• Design and apply biophysical and biochemical characterisation methods (SPR/BLI, ELISA, etc.).
• Evaluate affinity, kinetics, specificity, and developability characteristics.
• Integrate datasets to support clear candidate-selection decisions and go/no-go decisions.
• Coordinate internal resources and manage external CROs and partners.
• Communicate strategy, data, risks and recommendations to senior stakeholders.

Skills

Antibody biophysics

SPR/BLI

Programme leadership

Data integration

Cross-functional collaboration

Mentoring

CRO management

Biophysics expertise

Education

PhD in Biochemistry/Biophysics

Tools

SPR

BLI

Job description

Northreach seeks a Principal Scientist to lead antibody characterisation and candidate-selection across its preclinical discovery efforts. The role blends deep biophysics with programme ownership and cross-functional collaboration with discovery, computational teams and external partners.

You will shape experimental strategies, assess large panels of antibody candidates, and drive decisions to progress molecules toward preclinical development.