In Vivo Pharmacology Lead — Kidney/Metabolic

Sygnature Discovery; Nottingham; On-site; GBP 65,000 - 95,000; Full time

Benefits offered by this job

25 days annual leave

Employee Assistance Programme

Enhanced Family Friendly Policies

Job summary

Sygnature Discovery is seeking two Associate Principal Scientists to join our In Vivo Pharmacology team in Nottingham. One specialist will focus on kidney disease and the other on metabolic disease.

You will design, lead and deliver high-quality in vivo studies and influence multiple client-driven drug discovery programmes. You will act as a project lead, collaborate with internal teams and external clients, mentor team members and help shape experimental strategy with innovative approaches.

Qualifications

• PhD in a relevant discipline with industry or postdoctoral drug discovery experience or BSc/MSc with substantial industry experience in drug discovery.
• Strong expertise in kidney disease, inflammation and/or metabolic disorders.
• Proven experience applying in vivo pharmacology models in drug discovery; expertise in relevant ex vivo assays is highly desirable.
• Experience with end-to-end drug discovery workflows and industrial drug discovery is advantageous.
• Strong understanding of UK regulations governing in vivo research.
• Demonstrated experience in study design, oversight and data interpretation.
• Strong organisational and project management capabilities, with the ability to manage multiple projects simultaneously.
• Effective communicator with proven ability to collaborate across teams and with clients.

Responsibilities

• Lead the design, execution and interpretation of in vivo pharmacology studies within kidney, inflammation and/or metabolic disease programmes.
• Act as Project Lead, coordinating multidisciplinary teams to deliver high-quality, timely outcomes for client projects.
• Provide scientific leadership and technical expertise, guiding experimental strategy and solving complex research challenges.
• Drive innovation, implementing novel experimental approaches and technologies to enhance project success and improve scientific capabilities and workflows within the department.
• Collaborate closely with internal teams and external clients, contributing to study design, data interpretation and scientific discussions.
• Support and mentor team members; line management responsibilities may form part of this role.

Skills

Kidney disease

Metabolic disease

In vivo pharmacology

Ex vivo assays

Drug discovery

Regulatory awareness

Study design

Project management

Client collaboration

Education

PhD in relevant discipline

BSc/MSc with industry experience

Job description

Sygnature Discovery is seeking two Associate Principal Scientists to join our In Vivo Pharmacology team in Nottingham. One specialist will focus on kidney disease and the other on metabolic disease.

You will design, lead and deliver high-quality in vivo studies and influence multiple client-driven drug discovery programmes. You will act as a project lead, collaborate with internal teams and external clients, mentor team members and help shape experimental strategy with innovative approaches.