In Vivo Neurophysiology Scientist - Patch-Clamp & 2P

Convergent Research; Greater London; On-site; GBP 60,000 - 75,000; Full time

Job summary

Meridial seeks an experienced Scientist – In Vivo Neurophysiology to advance its cutting-edge platform for functional mapping of neural circuits. The role combines intracellular electrophysiology, high-resolution two-photon imaging and optogenetic stimulation in mice, with a focus on establishing ground-truth measurements for optical mapping approaches.

You will develop new methods, conduct longitudinal experiments, and help interpret optical data while collaborating with engineers and

Qualifications

• PhD or equivalent in neuroscience or related field.
• 3+ years hands-on whole-cell patch-clamp experience.
• Experience with craniotomy and headplate implantation.
• In vivo two-photon microscopy experience.
• Strong understanding of neuronal physiology and biophysics.
• Ability to design well-controlled experiments translating questions into designs.
• Proficiency in Python and/or MATLAB for data analysis.
• Willingness to complete UK Home Office Personal Licence training if needed.
• Commitment to animal welfare and rigorous experimental practice.
• Strong communication and collaborative skills.

Responsibilities

• Develop and perform high-quality in vivo whole-cell patch-clamp recordings with two-photon guidance and optical stimulation.
• Contribute to analysis of electrophysiological and imaging data.
• Design and run in vivo experiments combining two-photon imaging and optogenetic stimulation, including longitudinal imaging.
• Perform neurosurgical procedures for in vivo electrophysiology and imaging.
• Monitor recording and imaging quality, physiological stability and animal welfare, addressing noise and artefacts.
• Set up the in vivo electrophysiology rig with in-house experts, integrating acquisition with imaging and stimulation.
• Lead development and validation of targeted patching methods and reproducible workflows.
• Collaborate with the Computational Team on analysis workflows and data standards.

Skills

Patch-clamp electrophysiology

Two-photon imaging

Optogenetics

In vivo electrophysiology

Neurosurgical preparation

Python/MATLAB

Neuronal physiology

Data analysis

Troubleshooting electrophysiology

Education

PhD in neuroscience or related field

Tools

Two-photon microscope

Electrophysiology rig

Surgical equipment

Job description

Meridial seeks an experienced Scientist – In Vivo Neurophysiology to advance its cutting-edge platform for functional mapping of neural circuits. The role combines intracellular electrophysiology, high-resolution two-photon imaging and optogenetic stimulation in mice, with a focus on establishing ground-truth measurements for optical mapping approaches.

You will develop new methods, conduct longitudinal experiments, and help interpret optical data while collaborating with engineers and