In Vivo Neuroscience Associate — Two-Photon Imaging & Optogenetics

Convergent Research; Greater London; On-site; GBP 45,000 - 65,000; Full time

Job summary

Meridial in London seeks an Associate Scientist – In Vivo Neuroscience to perform survival neurosurgery in mice, cranial-window implantation and long-term imaging using two-photon systems, advancing 3D mapping of neural circuits.

You will work with engineers and computational researchers, develop protocols, and contribute to open-data workflows, with mentoring from senior scientists and a small experimental team.

Qualifications

• Hands-on experience with mouse neurosurgery and in vivo two-photon imaging.
• Experience setting up longitudinal imaging experiments in mice.
• Familiarity with optogenetic approaches and data recording.

Responsibilities

• Perform survival neurosurgery in mice, including stereotaxic viral injections, cranial-window implantation and preparation of animals for chronic imaging and manipulation.
• Carry out high-quality in vivo two-photon imaging, including longitudinal imaging of the same animals over weeks to months.
• Run optogenetic experiments to interrogate and manipulate neural circuits.
• Support the implementation of viral and transgenic strategies for functional imaging, circuit manipulation and anatomical investigation.
• Support animal colony management, working with senior team members and animal facility staff, including tracking breeding and experimental requirements.
• Monitor preparation quality and animal welfare throughout longitudinal studies and help identify and resolve technical problems with more senior scientists.
• Maintain accurate and comprehensive records of experimental procedures and outcomes.

Skills

Mouse neurosurgery

In vivo two-photon imaging

Optogenetics

Longitudinal animal imaging

Experimental protocol development

Tools

Two-photon microscope

Stereotaxic apparatus

Virus injections

Job description

Meridial in London seeks an Associate Scientist – In Vivo Neuroscience to perform survival neurosurgery in mice, cranial-window implantation and long-term imaging using two-photon systems, advancing 3D mapping of neural circuits.

You will work with engineers and computational researchers, develop protocols, and contribute to open-data workflows, with mentoring from senior scientists and a small experimental team.