FA iPSC Neuron Modeling – Research Associate

The University of Sheffield; Sheffield; Hybrid; GBP 39.000 - 47.000; Vollzeit

Benefits dieser Stelle

41 days annual leave

Hybrid working

Generous pension scheme

Discounts and rewards

Staff networks

Development opportunities

Zusammenfassung

The University of Sheffield invites applications for a Research Associate to join SITraN and work on cellular mechanisms underlying Friedreich's ataxia using human iPSC-derived neuronal models. You will plan, execute and analyse experiments, develop new approaches, and contribute to publications and funding proposals.

The role emphasizes collaboration across neuroscience and molecular biology disciplines, with opportunities to present findings, mentor students, and support future research

Qualifikationen

• PhD in Neuroscience or related subject – essential
• Experience with induced pluripotent stem cell (iPSC) models – essential
• Demonstrated ability to work in collaborative, multidisciplinary teams – essential
• Experience with maintaining and differentiating iPSCs, or related neuronal assays – desirable

Aufgaben

• Plan, conduct and interpret experimental research on FA mechanisms and therapeutic compounds.
• Generate and differentiate iPSC-derived neuronal models; maintain cultures.
• Develop, optimise and validate protocols; troubleshoot technical issues.
• Apply ICC, fluorescence microscopy, RNA extraction, qPCR/ RNA sequencing.
• Integrate cellular, electrophysiological and molecular data to test hypotheses.
• Maintain meticulous lab records and inventories for reproducibility.
• Contribute to publications, conferences and grant applications.
• Provide guidance to students and junior researchers as needed.

Kenntnisse

Collaborative research

Data analysis

Scientific writing

Ausbildung

PhD in Neuroscience or related subject

Tools

iPSC culture and differentiation

Immunocytochemistry

Fluorescence microscopy

Patch-clamp electrophysiology

RNA sequencing

Jobbeschreibung

The University of Sheffield invites applications for a Research Associate to join SITraN and work on cellular mechanisms underlying Friedreich's ataxia using human iPSC-derived neuronal models. You will plan, execute and analyse experiments, develop new approaches, and contribute to publications and funding proposals.

The role emphasizes collaboration across neuroscience and molecular biology disciplines, with opportunities to present findings, mentor students, and support future research