Director Manufacturing

AstraZeneca; Macclesfield; On-site; GBP 120,000 - 190,000; Full time

Job summary

AstraZeneca is seeking a Director for Manufacturing in Macclesfield to lead a multi-disciplinary team responsible for process execution, production, material usage and inventory for next-supply chain customers under VMI.

You will drive transformational change, ensure regulatory and financial policy compliance, and align resources to achieve budgets while maintaining licenses and stakeholder relationships across the site and larger EMEA region.

Qualifications

• Bachelor’s Degree in Manufacturing, Engineering, Science, Supply Chain Management (or related field).
• Significant experience in manufacturing and supply chain.
• Aseptic or sterile manufacturing experience.
• Proven leadership promoting motivation and empowering others to accomplish objectives.
• Ability to lead cross functional working groups; set priorities, resources and targets.
• Proven negotiation, collaboration and interpersonal leadership skills.
• Budgetary and resource management planning experience.
• Conceptual, analytical and strategic thinking.
• Effective problem and conflict resolution skills and proven team focus.
• Experience in managing projects in a pharmaceutical environment.

Responsibilities

• Lead a multi-disciplinary team responsible for processes within the PET; oversee production, materials and assets.
• Ensure compliance with cGMP, SHE, SOX and business procedures; manage budgets.
• Maintain capacity and capability to meet demand; manage stakeholder relationships.
• Contribute to site/EMEA leadership strategy and decision-making.

Skills

Leadership

Manufacturing

Supply Chain

Aseptic Manufacturing

Cross-functional

Budgeting

Strategic thinking

Negotiation

Project management

Regulatory compliance

Education

Bachelor’s Degree in Manufacturing

Job description

Macclesfield

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people's lives better. We thrive in our often intense and ambiguous environment, seeking out new challenges and working towards new solutions. We are part of an inclusive and giving community, supporting each other on our journeys. We are leading the way in delivering Lean processes that drive greater efficiency and speed. Sustainable practices are at the heart of what we do, ensuring we manage our environmental impact across all our activities and products

Introduction to role

The Director for Manufacturing will play a pivotal role in leading a multi-disciplinary team. You will be accountable for the overall performance of all processes within the boundaries of your Process Execution Team (PET) control. This includes production, material and asset utilization, support, and inventory in process as supplied to next supply chain customer under Vendor Managed Inventory.

Accountabilities

You will be leading a team through transformational change, ensuring compliance with AZ’s financial policies, managing people resources to policy requirements, and delivering budgets. You will be responsible for maintaining compliance in accordance with cGMP, SHE, SOX and business procedures, ensuring capacity and capability is in place to meet demand, maintaining compliance within licenses to operate, managing stakeholder relationships, and contributing to site/EMEA leadership strategy and decision-making.

Essential Skills/Experience

• Bachelor’s Degree in Manufacturing, Engineering, Science, Supply Chain Management (or related field) or equivalent experience
• Significant experience in manufacturing and supply chain
• Aseptic or sterile manufacturing experience
• Proven leadership promoting motivation and empowering others to accomplish individual, team and organizational objectives
• Ability to lead cross functional working groups and teams; Demonstrated ability to set and manage priorities, resources, performance targets and project initiatives in a regional environment
• Proven negotiation, collaboration and interpersonal leadership skills
• Budgetary and resource management planning experience
• Conceptual, analytical and strategic thinking

Desirable Skills/Experience

• Effective problem and conflict resolution skills and proven team focus
• Experience in managing projects in a pharmaceutical environment

At AstraZeneca, we are leading our Operations function at an exciting time of growth and evolution. We pioneer new approaches and processes across our sites, empowering our teams to foster a Lean mindset and sustainable practices. Every change we make is to deliver better outcomes for our patients. We are the champions of Lean, ensuring our teams understand and embody the benefits it can bring. There's improved quality and safety, as well as speed. Our manufacturing sites are environments of constant and rapid change. It's a place to expect the unexpected. There's rarely an obvious answer to the varied challenges we face, so it takes adaptability, flexibility and patience to thrive here.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions.

Date Posted

18-Sept-2026

Closing Date

04-Oct-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.