Director Manufacturing

AstraZeneca GmbH; Macclesfield; On-site; GBP 120,000 - 180,000; Full time

Job summary

AstraZeneca in Macclesfield seeks a Director of Manufacturing to lead a multi-disciplinary team and drive performance across processes including production, material and asset utilization, and inventory within the PET. The role focuses on delivering efficient, compliant operations in a fast-paced environment.

The successful candidate will ensure cGMP/SHE/SOX compliance, manage budgets, and guide transformational change while partnering with site and EMEA leadership to meet demand and optimize

Qualifications

• Bachelor’s Degree in Manufacturing, Engineering, Science, Supply Chain Management (or related field) or equivalent experience
• Significant experience in manufacturing and supply chain
• Aseptic or sterile manufacturing experience
• Proven leadership promoting motivation and empowering others to accomplish objectives
• Ability to lead cross functional working groups and teams; set and manage priorities, resources, performance targets and project initiatives in a regional environment
• Proven negotiation, collaboration and interpersonal leadership skills
• Budgetary and resource management planning experience
• Conceptual, analytical and strategic thinking

Responsibilities

• Lead a multi-disciplinary team through transformational change
• Ensure compliance with cGMP, SHE, SOX and business procedures
• Deliver budgets and manage people resources to policy requirements
• Maintain capacity and capability to meet demand and licenses to operate

Skills

Leadership

Cross-functional teamwork

Strategic thinking

Negotiation

Budgeting

People management

Education

Bachelor’s Degree in Manufacturing, Engineering, Science, or related field

Job description

Director Manufacturing

Macclesfield

At AstraZeneca, we are driven by our commitment to deliver accelerated growth and to make people's lives better. We thrive in our often intense and ambiguous environment, seeking out new challenges and working towards new solutions. We are part of an inclusive and giving community, supporting each other on our journeys. We are leading the way in delivering Lean processes that drive greater efficiency and speed. Sustainable practices are at the heart of what we do, ensuring we manage our environmental impact across all our activities and products

Introduction to role

The Director for Manufacturing will play a pivotal role in leading a multi-disciplinary team. You will be accountable for the overall performance of all processes within the boundaries of your Process Execution Team (PET) control. This includes production, material and asset utilization, support, and inventory in process as supplied to next supply chain customer under Vendor Managed Inventory.

Accountabilities

You will be leading a team through transformational change, ensuring compliance with AZ’s financial policies, managing people resources to policy requirements, and delivering budgets. You will be responsible for maintaining compliance in accordance with cGMP, SHE, SOX and business procedures, ensuring capacity and capability is in place to meet demand, maintaining compliance within licenses to operate, managing stakeholder relationships, and contributing to site/EMEA leadership strategy and decision-making.

Essential Skills/Experience

• Bachelor’s Degree in Manufacturing, Engineering, Science, Supply Chain Management (or related field) or equivalent experience

• Significant experience in manufacturing and supply chain

• Aseptic or sterile manufacturing experience

• Proven leadership promoting motivation and empowering others to accomplish individual, team and organizational objectives

• Ability to lead cross functional working groups and teams; Demonstrated ability to set and manage priorities, resources, performance targets and project initiatives in a regional environment

• Proven negotiation, collaboration and interpersonal leadership skills

• Budgetary and resource management planning experience

• Conceptual, analytical and strategic thinking

Desirable Skills/Experience

• Effective problem and conflict resolution skills and proven team focus

• Experience in managing projects in a pharmaceutical environment

At AstraZeneca, we are leading our Operations function at an exciting time of growth and evolution. We pioneer new approaches and processes across our sites, empowering our teams to foster a Lean mindset and sustainable practices. Every change we make is to deliver better outcomes for our patients. We are the champions of Lean, ensuring our teams understand and embody the benefits it can bring. There's improved quality and safety, as well as speed. Our manufacturing sites are environments of constant and rapid change. It's a place to expect the unexpected. There's rarely an obvious answer to the varied challenges we face, so it takes adaptability, flexibility and patience to thrive here.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions.

Date Posted

18-Sept-2026

Closing Date

04-Oct-2026

Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.