CryoEM Research Fellow: Amyloid Structure & Disease

Leeds; Leeds; On-site; GBP 41,000 - 49,000; Full time

Benefits offered by this job

26 days holiday + 16 bank holidays

Generous pension scheme options

On-site childcare, shopping discounts,

Job summary

University of Leeds seeks an outstanding Research Fellow to join an interdisciplinary team investigating how amyloid fibrils form and affect neuronal function. The post focuses on cryoEM studies, complemented by biochemical and biophysical analyses, to map fibril structures and their biological impact.

The successful candidate will work with Profs. Sheena Radford and Neil Ranson on collaborations and will contribute to understanding disease-relevant mutations and modifications, in a 18-month

Qualifications

• PhD in Structural Biology, Biochemistry or related field (or close to completion) with strong background in cryoEM.
• Experience applying cryoEM to problems in protein structure, assembly, and cellular mechanisms.
• Ability to work in an interdisciplinary team and collaborate across institutions.

Responsibilities

• Conduct cryoEM and complementary biochemical/biophysical analyses to characterize amyloid fibrils formed in vitro and from patient samples.
• Investigate how different fibril structures perturb neuronal function and relate to disease-related mutations/modifications.
• Collaborate with Profs. Radford and Ranson and external partners on project milestones.

Skills

CryoEM techniques

Structural biology

Biochemistry

Education

PhD in Structural Biology/Biochemistry or related (or near completion)

Tools

CryoEM hardware

Protein structure analysis

Job description

University of Leeds seeks an outstanding Research Fellow to join an interdisciplinary team investigating how amyloid fibrils form and affect neuronal function. The post focuses on cryoEM studies, complemented by biochemical and biophysical analyses, to map fibril structures and their biological impact.

The successful candidate will work with Profs. Sheena Radford and Neil Ranson on collaborations and will contribute to understanding disease-relevant mutations and modifications, in a 18-month