Associate Scientist, iPSC-Derived Neuronal Models

Hlx Life Sciences; Greater London; On-site; GBP 32,000 - 52,000; Full time

Job summary

Hlx Life Sciences is seeking an Associate Scientist/Technician to support CNS biology research using human iPSC-derived neuronal models. This laboratory-based role focuses on in vitro studies to advance discovery and development of novel therapeutics.

The successful candidate will establish and maintain iPSC-derived neuronal cultures, differentiate cells, and perform routine culture and quality control. Strong experience with immunocytochemistry, ELISA, Western blot and qPCR is essential.

Qualifications

• Hands-on experience culturing and maintaining human iPSC-derived neurons.
• Experience differentiating hiPSCs into neuronal cell types and supporting maturation.
• Experience with immunocytochemistry, ELISA, Western blot, RNA/DNA extraction, qPCR/RT-qPCR.
• Ability to work collaboratively within a drug-discovery team.
• Strong analytical, problem-solving and organisational skills; health & safety awareness.

Responsibilities

• Establish, maintain and differentiate human iPSC-derived neuronal cultures.
• Perform routine culture of iPSC-derived neurons including seeding, media prep, differentiation, maturation, passaging, cryopreservation, thawing and QC.
• Support pharmacological studies including compound preparation, dose‑response and analysis using biochemical and cellular assays.
• Develop and optimize neuronal models and assays for CNS drug discovery.
• Maintain lab organisation, reagent preparation, equipment maintenance and inventory control.

Skills

iPSC-derived neurons culture

Neuronal differentiation

Immunocytochemistry

Western blotting

ELISA

qPCR/RT-qPCR

RNA/DNA extraction

Data analysis

Collaborative teamwork

Lab safety

Education

BSc or MSc in biology/related field

Tools

ELISA equipment

Western blot apparatus

Cryopreservation equipment

Job description

Hlx Life Sciences is seeking an Associate Scientist/Technician to support CNS biology research using human iPSC-derived neuronal models. This laboratory-based role focuses on in vitro studies to advance discovery and development of novel therapeutics.

The successful candidate will establish and maintain iPSC-derived neuronal cultures, differentiate cells, and perform routine culture and quality control. Strong experience with immunocytochemistry, ELISA, Western blot and qPCR is essential.