Associate Principal Scientist/Principal Scientist (Medicinal Chemistry)

Sygnature Discovery; Macclesfield; On-site; GBP 80,000 - 110,000; Full time

Benefits offered by this job

25 days annual leave

Employee Assistance Programme

Enhanced Family Friendly Policies

Job summary

Sygnature Discovery is seeking an Associate Principal Scientist / Principal Scientist in the Chemistry team at Alderley Park. You will lead multidisciplinary medicinal chemistry programmes, shape project strategy and mentor scientists to drive successful outcomes across diverse drug discovery projects.

The role emphasizes collaboration across Bioscience and DMPK, with responsibility for stakeholder communication and external representation. Senior expertise and industry experience are essential.

Qualifications

• PhD in Organic Chemistry, Medicinal Chemistry, or a related discipline, or equivalent industrial experience.
• Proven track record of leading multidisciplinary drug discovery projects and delivering scientific success.
• Broad understanding of integrated drug discovery and ability to work across multiple disciplines.
• Strong people leadership skills with experience mentoring scientists.
• Excellent communication and stakeholder management with the ability to influence diverse audiences.
• Commercial awareness and experience with clients, proposals, and business growth.

Responsibilities

• Lead and influence complex medicinal chemistry programmes, at any stage of pre-clinical development.
• Develop high performing project teams, ensuring delivery of excellent science and successful outcomes.
• Communicate scientific strategy and project outcomes to internal and external stakeholders.
• Provide leadership beyond project delivery by contributing to operational strategy and growth.
• Mentor, coach and train scientists to develop their careers.
• Maintain laboratory standards, data integrity, safety, and compliance.

Skills

Leadership

Stakeholder management

Communication

Mentoring

Education

PhD in Organic/Medicinal Chemistry

Job description

At Sygnature Discovery, we create exceptional scientific outcomes. For our customers, who bring life-changing medicines to patients; and for our people, who help make this possible.

We’re 700+ scientists from over 50 countries, working as one across Europe and North America. With no competing internal programs, we offer total confidentiality and commitment.

Over the past 20 years, we’ve earned a track record of real impact: 60+ advanced candidates, 250 patents filed, 200+ active projects. Over 90% of our customers choose to stay with us – from biotechs racing to clinic to pharma companies that need specialised expertise for targeted challenges.

About the role:

Our Chemistry team at Alderley Park is looking for an experienced Associate Principal Scientist / Principal Scientist to join the team.

We’re looking for someone with significant experience leading medicinal chemistry programmes within a pharmaceutical, biotechnology or CRO environment. This is a senior and influential role where you’ll help shape project strategy, develop high-performing scientists through effective mentoring and coaching, and contribute to the continued growth and success of the site.

You’ll work closely with colleagues across Bioscience and DMPK and other scientific disciplines to define and execute integrated project strategies. Strong experience of working within multidisciplinary drug discovery teams, influencing scientific direction and communicating effectively with both internal teams and clients, will therefore be essential.

This is a fantastic opportunity to work across diverse drug discovery projects for a range of clients, offering genuine breadth and depth of scientific experience.

Role Responsibilities:

• Lead and influence complex medicinal chemistry programmes, at any stage of pre-clinical development
• Develop high performing project teams, ensuring the delivery of excellent science and successful project outcomes.
• Communicate scientific strategy and key project outcomes, whilst simultaneously manage all stakeholders, both internal and external
• Provide leadership beyond project delivery by contributing to operational strategy, business growth, recruitment, capability development, and continuous improvement programmes across the department.
• Contribute to the development of high-performing scientists through effective mentoring, coaching, training, and performance management.
• Maintain the highest standards of laboratory practice, data integrity, health & safety, and professionalism, ensuring teams are appropriately trained, fully compliant with all relevant company policies, and consistently maintain a safe and productive working environment.
• Represent Sygnature externally through client engagement, scientific presentations, publications, conference participation, and professional networking activities.

Skills & Qualifications:

• PhD in Organic Chemistry, Medicinal Chemistry, or a related discipline, or equivalent industrial experience.
• Proven track record of leading multidisciplinary drug discovery projects and delivering scientific success.
• Broad understanding of integrated drug discovery and the ability to work effectively across multiple scientific disciplines.
• Strong people leadership skills, with experience mentoring, coaching, and developing scientists at different career stages.
• Excellent communication and stakeholder management skills, with the ability to influence both scientific and non-scientific audiences.
• Commercial awareness and experience working with clients, supporting proposals, and contributing to business growth.
• Motivated, adaptable, and comfortable operating in a fast-paced and collaborative environment.

25 days annual leave (plus bank holidays)

Employee Assistance Programme

Enhanced Family Friendly Policies