Job offer

European Commission; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

The European Commission is seeking a highly motivated post-doctoral fellow to explore translation regulation during megakaryopoiesis. The role requires a PhD in Biological Sciences with strong expertise in molecular biology and biochemistry. The postdoc will work in a collaborative research environment, utilizing state-of-the-art equipment and receiving career development mentorship.

Prestations

Close supervision and mentoring

Access to state-of-the-art equipment

Stimulating scientific environment

Qualifications

• Strong background in molecular biology and biochemistry.
• Good record of publications, preferably within 2 years post-PhD.
• Knowledge in cell culture, western blot, immune-fluorescence and RNAseq.

Responsabilités

• Work on translation regulation during megakaryopoiesis.
• Identify the role of ribosomal protein RPS6 in this process.
• Interact with interdisciplinary groups and receive career mentoring.

Connaissances

Molecular Biology

Biochemistry

Cell Culture

Western Blot

Immune-Fluorescence

RNAseq

Mouse Handling

Microscopy

Formation

PhD in Biological Sciences

Description du poste

Organisation/Company GIN Grenoble Institut des Neurosciences Research Field Biological sciences » Biology Chemistry » Biochemistry Researcher Profile Recognised Researcher (R2) Leading Researcher (R4) First Stage Researcher (R1) Established Researcher (R3) Country France Application Deadline 15 Jul 2025 - 22:00 (UTC) Type of Contract Temporary Job Status Full-time Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

We seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation and mechanisms during megakaryopoiesis. The candidate needs to hold a PhD with good record of publications,

preferentially with no more than 2 years after getting PhD. Candidate needs to have a strong background in molecular biology and biochemistry with knowledge in cell culture, western blot, immune-fluorescence and

RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc will

have access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups and will receive mentoring for career development.

Background: Over the past decade, genetic lesions that cause ribosome dysfunctions have been identified in
both congenital and acquired human disorders. These ribosome modifications can directly impact translation
levels and quality in cells. Very recent data underline that ribosome biogenesis is involved in mediating the
transition between proliferation and differentiation of erythroid progenitors. The functional consequences of
translation and protein synthesis regulation on megakaryopoiesis remains largely unexplored. Our preliminary
data suggest that translation regulation and modification of the ribosomal protein RPS6 might have a critical
role in the megakaryopoiesis and platelet formation.
The goal of the postdoctoral project is to determine the role of the translation regulation during
megakaryopoiesis and to explore the potential roles of the ribosomal protein RPS6 in this process.
Qualification: We seek an enthusiastic, highly motivated post-doctoral fellow to work on translation regulation
and mechanisms during megakaryopoiesis. The candidate needs to hold a PhD with good record of publications,
preferentially with no more than 2 years after getting PhD. Candidate needs to have a strong background in
molecular biology and biochemistry with knowledge in cell culture, western blot, immune-fluorescence and
RNAseq. Additional knowledge in mouse handling and microscopy is a plus. We offer a close supervision in
both motivated teams and a stimulating scientific environment for a transdisciplinary project. The postdoc will
have access to state-of-the-art equipment related to the project. She/he will interact with interdisciplinary groups
and will receive mentoring for career development.