Senior Scientist, AI @Brink Therapeutics

Brink Therapeutics is a venture-backed biotech company specializing in the development of cutting-edge gene therapy tools. We focus on site-specific recombinases, highly efficient enzymes that enable precise DNA modifications—such as inserting, removing, or inverting DNA sequences—without causing double-strand breaks. These recombinases offer a safer, more precise alternative to existing technologies like CRISPR-Cas9, giving them the potential to revolutionize Cell and Gene Therapies and finally push them over the brink of mass accessibility.

Values

By joining Brink Therapeutics, you will become one of our first team members, and experience the thrill of helping to build an ambitious new company harnessing advanced Directed Evolution, deep gene-mining techniques and AI to unlock new possibilities for treating & curing cancers, autoimmune diseases, genetic disorders and beyond.

If you are an innovative scientist or engineer excited about working together to solve hard, longstanding problems to improve patients’ lives around the world, we are looking for passionate individuals to join our team and help shape the future of medicine!

Mission Highlights

As a Senior Scientist in AI, you will be responsible for developing AI models to accelerate therapeutic recombinase design, in close collaboration with the Molecular and Computational Biology teams. Your ultimate goal will be to support the wet-lab team in generating lead recombinase candidates of high therapeutic utility, leveraging our massive internal recombinase functional datasets to develop best-in-class genAI models for recombinase design.

Responsibilities

• Inform our wet-lab and bioinformatic data generation strategy to maximize the value of our internal training data
• Develop and benchmark best-in-class recombinase design models, trained on our unprecedented internal datasets
• Use models to inform Directed Evolution library design and generate high-performing lead recombinase design candidates
• Communicate project status, requirements, risks and mitigation to stakeholders
• Maintain detailed documentation, present results to stakeholders
• Disclose innovations to internal stakeholders to secure IP protection
• Mentor & coach junior team members

You have experience in applying AI to solve problems in biological sequence space, and are capable of quickly and self-sufficiently entering into new domains. You are highly organized and enjoy managing complex workloads while clearly documenting and communicating results in an actionable manner to both wet-lab and computational scientists. You are a sharp and collaborative trouble-shooter who doesn’t shy away from the hard problems and takes joy in working towards ambitious goals as a pluridisciplinary team.

Required:

• MSc with 5+ years of experience or PhD with 2+ years of experience in AI, computational biology or related fields, and eagerness to keep learning
• Proven record of innovative and independent problem-solving skills
• Demonstrated expertise in designing, developing, training and executing AI models (incl. Python, Github, AWS)
• Excellent written and oral communication
• English - professional working proficiency
• Motivation to work in a flexible and fast-paced startup

The ideal candidate will also have some of the following:

• Experience working in startup environments
• Expertise in Directed Evolution, gene library design, NGS, genome editing, computational enzymology, computational structural biology

Recruitment Process

• We first check that your profile meets our requirements
• An introductory call with the CEO (and cofounder) Jonathan Naccache
• Technical interview with the CTO (and cofounder) Harry Kemble
• Value fit interviews with the rest of the team, on-site
• Unique opportunity to be part of an early-stage biotech company, shaping the future of genome editing for Cell and Gene Therapy
• Competitive salary + benefits package
• Beautiful, well-equipped offices & labs in the heart of Paris, filled with great plants and great people

If you're excited about helping revolutionize genome editing and opening up Cell & Gene Therapy to the millions who could benefit, apply now, and let's make the difference together.