Senior Microfluidics Engineer (oil and surfactants)

Rivercell; Paris; Sur place; EUR 70 000 - 100 000; Plein temps

Avantages offerts par ce poste

Equity

Hands-on startup environment

Competitive salary

Résumé du poste

Rivercell in Paris is seeking a hands-on Microfluidics Engineer to develop the fluidic operating system of Rivercell's platform and enable high-throughput cell biology. You will select and optimize carrier oils, surfactants, and formulations to control droplets while preserving cell viability, and you will bridge microfluidics with interfacial chemistry and cell biology.

The role involves close collaboration with device integration, surface engineering, and biology teams, and offers equity in an

Qualifications

• PhD in microfluidics, chemical engineering, physical chemistry, soft matter, bioengineering, biophysics, or related field.
• 4+ years of hands-on experience developing microfluidic systems, multiphase formulations, emulsions, or droplet-based assays.
• Strong understanding of wetting, interfacial tension, surfactants, emulsions, and transport phenomena.
• Fluency in English; professional French helpful but not required.

Responsabilités

• Select and optimize carrier oils based on viscosity, conductivity, stability, and biocompatibility.
• Select and optimize surfactants to control droplet stability, wetting, and cell adhesion.
• Build formulation maps linking composition, temperature, droplet size, and actuation performance.
• Evaluate formulations for cell viability, morphology, and assay performance.
• Adapt fluidic system to complex media including salts, serum, proteins, and cells.
• Characterize interfacial tension, viscosity, and emulsion stability.
• Minimize cross-talk, reagent loss, and contamination between droplets.
• Define chip priming, loading, bubble-removal, and cleaning procedures.
• Design diagnostic experiments and translate results into specifications.

Connaissances

Droplet microfluidics

Digital microfluidics

Electrowetting

Emulsions

Lab-on-a-chip systems

Interfacial chemistry

Mass transfer

Transport phenomena

Formation

PhD in microfluidics, chemical engineering, physical chemistry, or related field

Outils

Fluorinated oils

Fluorosurfactants

Non-ionic surfactants

Custom amphiphilic formulations

Description du poste

We are looking for a hands-on Microfluidics Engineer to develop the fluidic operating system of Rivercell's platform and make it compatible with robust, high-throughput cell biology.

You will own the selection and optimization of carrier oils, surfactants, aqueous formulations, and operating protocols that enable reliable droplet manipulation while preserving cell viability and biological function. You will bridge microfluidics, interfacial physical chemistry, and cell biology.

You will work hand-in-hand with our device integration lead, surface engineering scientist, thin-film materials engineer, characterization engineer, assembly team, and cell biology team. You will also collaborate with an interdisciplinary group spanning genetic engineering, AI and software, bio-laboratory automation, optics, and electronics, and be an integral part of an ambitious startup project from its inception.

• Select and optimize carrier oils based on viscosity, dielectric properties, conductivity, optical transparency, volatility, gas permeability, chemical stability, and biological compatibility

• Select and optimize surfactants and interfacial additives to control droplet stability, coalescence, wetting, pinning, protein adsorption, and cell adhesion

• Build formulation maps linking oil and surfactant composition, concentration, temperature, droplet size, waveform, frequency, and actuation performance

• Evaluate formulations for cell viability, proliferation, morphology, membrane integrity, phenotype, and assay performance over relevant experimental durations

• Adapt the fluidic system to complex media containing salts, serum, proteins, extracellular matrices, drugs, dyes, nucleic acids, and suspended cells

• Characterize interfacial tension, viscosity, dynamic wetting, emulsion stability, evaporation, gas exchange, and the partitioning of water, proteins, and small molecules

• Minimize cross-talk, reagent loss, fouling, osmotic drift, unwanted extraction, bubble formation, and contamination between droplets

• Define chip priming, loading, filling, bubble-removal, sample-recovery, cleaning, storage, and preconditioning procedures

• Design diagnostic experiments and translate results into formulation specifications, operating windows, quality controls, and standardized protocols

• Opportunity to work on a cutting-edge project in the field of biotech

• Opportunity to join an ambitious team and impactful startup among the first employees

• Competitive salary and equity package

• Exciting opportunities for personal and professional growth within the team

You have a PhD in microfluidics, chemical engineering, physical chemistry, soft matter, bioengineering, biophysics, or a related field.You have 4+ years of hands-on experience developing microfluidic systems, multiphase formulations, emulsions, or droplet-based assays.You have a strong understanding of wetting, capillarity, interfacial tension, surfactants, emulsions, mass transfer, and transport phenomena.You can connect fluid properties and interfacial mechanisms to measurable device performance and biological outcomes.You are comfortable exploring multidimensional formulation spaces and drawing practical conclusions from imperfect data.You are autonomous, committed, enthusiastic, and comfortable working with a can-do, creative, and challenging mindset.You are rigorous in experimental documentation, formulation traceability, data interpretation, and communication of uncertainty.You have excellent communication skills and are fluent in English; professional proficiency in French is helpful but not required.You have previous experience or knowledge in one or more of the following areas:Droplet microfluidics, digital microfluidics, electrowetting, emulsions, or lab-on-a-chip systemsFluorinated, silicone, or hydrocarbon oils; fluorosurfactants, non-ionic surfactants, block copolymers, or custom amphiphilic formulationsCell culture, cell-based assays, organoids, primary cells, immune cells, or other sensitive biological samplesTensiometry, contact-angle measurements, microscopy, particle tracking, or high-speed imagingDesign of experiments, formulation screening, statistical analysis, automated experimentation, or process development

Please let us know in your application if you specifically have experience with one or several of the following:Optimizing oil and surfactant systems for mammalian cell culture or long-duration biological experimentsQuantifying partitioning, adsorption, reagent loss, cross-talk, or small-molecule transport in droplet systemsWorking with fluorinated oils and biocompatible fluorosurfactants, including protein- or polymer-based surfactantsElectrowetting and the influence of conductivity, permittivity, viscosity, and waveformTransferring fluid formulations and priming, filling, bubble-management, recovery, and cleaning protocols into repeatable operation