Scientist / Junior Scientist in Biomolecular NMR Spectroscopy (M/F)

Novalix; Strasbourg; On-site; EUR 60,000 - 95,000; Full time

Job summary

Novalix in Strasbourg, France, seeks a dynamic NMR scientist to join the Structural Biology and Biophysics team under the Head of NMR, supporting pharmaceutical and biotechnology clients in their drug discovery programs.

You will design and perform advanced biomolecular NMR experiments, conduct ligand- and protein-observed assays, analyze complex data, develop new NMR methodologies, and present results to clients and internal teams.

Qualifications

• PhD in Structural Biology or Biophysics with strong theoretical and practical expertise in biomolecular NMR spectroscopy.
• Hands-on experience operating high-field NMR spectrometers (600, 700 and/or 800 MHz).
• Proven experience characterizing protein–ligand interactions using ligand- and/or protein-observed NMR approaches.
• Experience with multidimensional NMR experiments and resonance assignment strategies.

Responsibilities

• Design, perform and interpret advanced biomolecular NMR experiments for protein and protein-ligand characterization.
• Conduct ligand-observed and protein-observed NMR assays to support hit identification and fragment-based drug discovery.
• Perform multidimensional NMR analyses to characterize binding events and structural changes.
• Independently perform resonance assignments using state-of-the-art methodologies and computational tools.
• Analyze NMR datasets to provide structural and mechanistic insights for client projects.
• Contribute to development, validation and implementation of new NMR methodologies.
• Prepare protocols, SOPs and technical documentation.
• Present results to internal teams and clients through written and oral reports.
• Participate in troubleshooting and continuous improvement of NMR workflows and instrumentation.

Skills

Biomolecular NMR

NMR spectroscopy

High-field NMR

Fluent English

Education

PhD in Structural Biology

PhD in Biophysics

Tools

NMR software

Resonance assignment

Job description

Job Description

Under the supervision of the Head of NMR, you will join a multidisciplinary Structural Biology and Biophysics team supporting pharmaceutical and biotechnology clients in their drug discovery programs.

Working closely with experts in Surface Plasmon Resonance (SPR), Native Mass Spectrometry, HDX-MS, Cryo-EM and X-ray Crystallography, you will contribute to the characterization of biomolecular interactions and the structural investigation of proteins and protein-ligand complexes.

You will be expected to:

• Design, perform and interpret advanced biomolecular NMR experiments for protein and protein-ligand characterization.
• Conduct ligand-observed and protein-observed NMR assays to support hit identification, hit validation and fragment-based drug discovery projects.
• Perform multidimensional NMR analyses to characterize binding events, chemical shift perturbations and structural changes induced by ligand binding.
• Independently perform resonance assignments using state-of-the-art methodologies and computational tools.
• Analyze and interpret NMR datasets to provide structural and mechanistic insights supporting client projects.
• Contribute to the development, validation and implementation of new NMR methodologies and applications.
• Prepare protocols, SOPs and technical documentation.
• Present results to internal teams and clients through written and oral reports.
• Participate in troubleshooting activities and continuous improvement of NMR workflows and instrumentation.

Profile

We are looking for a dynamic, motivated and scientifically curious NMR scientist to join the Structural Biology and Biophysics team.

Major Requirements

• PhD in Structural Biology, NMR Spectroscopy, Biophysics
• Strong theoretical and practical expertise in biomolecular NMR spectroscopy.
• Hands-on experience operating high-field NMR spectrometers (600, 700 and/or 800 MHz).
• Proven experience in the characterization of protein-ligand interactions using ligand-observed and/or protein-observed NMR approaches.
• Experience with multidimensional NMR experiments and resonance assignment strategies.
• Ability to independently analyze complex datasets and derive biologically relevant conclusions.
• Excellent written and verbal communication skills in English.
• Strong organizational skills and ability to manage multiple projects simultaneously.
• Ability to work efficiently in a multidisciplinary and client-oriented environment.

Additional Assets

• Experience in fragment-based drug discovery (FBDD).
• Knowledge of complementary biophysical techniques such as SPR, MST, ITC, DLS or Native MS.
• Experience in method development and automation of NMR workflows.

Personal Skills

• Strong analytical and problem-solving abilities.
• Scientific rigor and experimental autonomy.
• Ability to translate complex structural information into actionable project recommendations.
• Excellent communication and presentation skills.
• Collaborative mindset and team spirit.
• Curious, innovative and proactive attitude.i>
• Strong client-service orientation.

Languages

• Fluent English, written and spoken.

Start of contract: as soon as possible.

Type of contract: permanent position.