Postdoc: Structural Biology & NMR for Antibody PTMs

Biopatrika; France; On-site; EUR 42,000 - 57,000; Full time

Job summary

Sanofi in Vitry-sur-Seine is seeking a Postdoctoral Fellow in the Biophysics & BioNMR / BioAnalytics team to investigate how PTMs in antibody CDRs affect antigen binding and stability using 2D/3D-NMR, cryo-EM, crystallography and HDX-MS. The role supports molecule optimization and manufacturing processes.

You will design experiments, produce samples, and collaborate across teams to advance projects in structural biology and biophysics for therapeutic development.

Qualifications

• PhD in NMR spectroscopy, structural biology, biophysics or a related field.
• Hands-on protein production with isotope labelling (e.g., U-13C, 15N, 2H) and methyl labelling; experience in NMR assignment of high molecular weight proteins.
• Fluent English; intermediate French.

Responsibilities

• Produce and characterize samples with different PTMs by MS, SEC, DSC and binding assays.
• Perform 2D-NMR analysis on modified and unmodified mAb/Fab samples to map chemical shift perturbations.
• Produce samples via cell-free expression.
• Structurally characterize Fab-antigen interactions by NMR, cryo-EM, crystallography and HDX-MS.
• Design, produce and evaluate mutated Fab constructs to probe roles of neighboring residues.
• Present findings to cross-functional teams and contribute to scientific publications.

Skills

NMR spectroscopy and protein labelling

Education

PhD in NMR spectroscopy or related field

Job description

Sanofi in Vitry-sur-Seine is seeking a Postdoctoral Fellow in the Biophysics & BioNMR / BioAnalytics team to investigate how PTMs in antibody CDRs affect antigen binding and stability using 2D/3D-NMR, cryo-EM, crystallography and HDX-MS. The role supports molecule optimization and manufacturing processes.

You will design experiments, produce samples, and collaborate across teams to advance projects in structural biology and biophysics for therapeutic development.