Research Engineer / Postdoctoral Researcher (M/F) – 24 months – Biostatistics and Multi-Omics Data Integration in Respiratory Health

University of Rouen Normandy; France; Sur place; EUR 42 000 - 55 000; Plein temps

Résumé du poste

University of Rouen Normandy, INSERM U1311 DYNAMICURE, is recruiting a research engineer or postdoctoral researcher specializing in biostatistics. You will analyze multi-omic datasets to link respiratory microbiomes with immune responses and clinical phenotypes, using advanced statistics and ML.

Based in Rouen, the 24-month term is funded and starts early 2027. The role offers exposure to a clinical cohort, metatranscriptomics, proteomics, and high-performance computing, with opportunities to

Qualifications

• Ph.D. in biostatistics or related field.
• Strong proficiency in R and Python; experience with HPC environments.
• Experience in NGS data analysis and multivariate statistics.
• Experience in multi-omics data integration and ML applied to biology.

Responsabilités

• Analyze complex multi-omic datasets to identify interactions between microbiomes, immune responses, and clinical phenotypes.
• Develop statistical models for longitudinal data.
• Integrate metatranscriptomic, transcriptomic, proteomic, and clinical data.
• Publish articles in international journals and present at conferences.
• Co-supervise Master students or interns.

Connaissances

R language

Python

Linux/Bash

HPC

NGS data analysis

Multivariate statistics

Multi-omics integration

Machine learning

French/English

Formation

Ph.D. in biostatistics, computational biology, mathematics, or an equivalent field

Outils

R

Python

Linux

HPC clusters

Description du poste

Organisation/Company University of Rouen Normandy Department Research unit DYNAMICURE UMR 1311 Research Field Biological sciences » Other Mathematics » Statistics Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Application Deadline 31 Dec 2026 - 23:59 (Europe/Paris) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 37:30 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Working laboratory:

INSERM U1311 DYNAMICURE is a research unit spanning two towns (University of Rouen Normandy and University of Caen Normandy). It specializes in the study of respiratory and urinary tract infections, their associated microbiomes, and host–microorganism interactions. The unit develops translational research approaches combining microbiology, genomics, immunology, bioinformatics, and clinical research. It benefits from a state-of-the-art technological environment (Asgard NGS platforms, HPC computing clusters).

The INSERM 1311 DYNAMICURE unit is recruiting a research engineer or postdoctoral researcher specializing in biostatistics. He or she will participate in the MICROBIOSTHME project, a translational research project aimed at understanding the role of the respiratory microbiota and immune responses in the pathophysiology of severe asthma in infants (preschool wheeze). This project is based on a prospective, multicenter cohort of 100 infants followed for one year, from whom upper and lower respiratory samples (nasopharyngeal swabs, bronchoalveolar lavages, and sputum) are collected. The project generates more than 1,000 respiratory samples, metatranscriptomic data (microbiome and host), proteomic profiles (Olink), and longitudinal clinical data, providing a unique platform for the development of statistical approaches and multi-omic integration.

The candidate will be based at UMR 1311 DYNAMICURE on the Rouen campus of the University of Rouen Normandy (Rouen School of Health Sciences, CRRIS research building, 22 Boulevard Gambetta, 76183 Rouen). The position is available starting in early 2027 for a term of 24 months, and funding has already been secured. The project began in 2022 and has since involved the establishment of a prospective cohort, obtaining regulatory approvals, and developing metatranscriptomics and bioinformatics analysis techniques through a doctoral program. Thirty percent of the omics data has already been generated and will be available for the candidate to work with upon arrival.

Responsibilities:

The successful candidate will join a multidisciplinary team comprising microbiologists, immunologists, pediatric pulmonologists, and bioinformaticians.The candidate’s primary responsibility will be to analyze complex multi-omic datasets to identify interactions between respiratory microbiomes, immune responses, and clinical phenotypes.

Their main responsibilities will include:

• Analysis of respiratory metatranscriptomic data.
• Analysis of human transcriptomic data from the same samples.
• Statistical integration of multi-omic data (metatranscriptomic, transcriptomic, proteomic, and clinical data).
• Development of statistical models for the analysis of longitudinal data.
• Identification of microbial and immune biomarkers associated with different endotypes of preschool wheezing.
• Development of predictive models using statistical learning and machine learning.
• Authoring articles for leading international journals and presenting at conferences.

Co-supervising master’s students or interns.

Scientific and Work Environment:

The candidate will work in a highly multidisciplinary environment, collaborating with microbiologists, immunologists, pediatric pulmonologists, and bioinformaticians. He or she will have access to a clinical cohort that is unique in France, as well as high-throughput sequencing and high-performance computing infrastructure. The candidate will have a high degree of scientific autonomy and will be encouraged to propose new methodological or statistical approaches to make the best use of the data generated by the project.

Living conditions:

Located just 1 hour and 15 minutes from Paris, Rouen is the capital of Normandy and a metropolitan area with more than 500,000 residents. A dynamic university city, it offers an excellent balance between quality of life and a vibrant academic environment, with a cost of living significantly lower than that of the Paris region. Its historic center, ranked among the most remarkable in France, its numerous cultural facilities, its natural spaces, and its proximity to the Normandy coast (less than an hour away) make it a particularly attractive place to live. Rouen also benefits from excellent rail connections to Paris and the rest of Normandy.

The University of Rouen Normandy is home to nearly 30,000 students and conducts renowned research in the fields of health, life sciences, and technology. The Health Campus brings together the Health Faculty (UFR Santé), the Rouen University Hospital (CHU), and several INSERM units, providing an environment particularly conducive to translational research.

Requirements

Research Field Biological sciences » Other Education Level PhD or equivalent

Research Field Mathematics » Other Education Level PhD or equivalent

Skills/Qualifications

• Ph.D. in biostatistics, computational biology, mathematics, or an equivalent field.
• Programming: very strong proficiency in R (required) and good skills in Python, the Linux/Bash environment, and the use of high-performance computing (HPC) clusters.
• Experience in NGS data analysis (RNA-seq, metagenomics, or metatranscriptomics) and multivariate statistics.

The following will be particularly valued:

• Experience in multi-omics data integration.
• Experience in microbiome or metagenomic analysis.

Experience in machine learning applied to biological data.

A very good level of French or English is required.

Specific Requirements

Languages ENGLISH Level Excellent

Languages FRENCH Level Excellent

Additional Information

Contract type: Fixed-Term Contract for Postdoctoral Researcher / Research Engineer (24 months)