Research Engineer in Molecular Biology and Spatial Transcriptomics (12-month contract ARC label[...]

European Commission; France; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

Un projet innovant de recherche en biologie moléculaire recherche un ingénieur spécialisé pour analyser la résistance des tumeurs au traitement. Vous intégrerez une équipe dédiée à la recherche translationnelle sur le cancer du pancréas, avec un accent sur les technologies avancées et l'interaction interdisciplinaire.

Qualifications

• Expérience solide en biologie moléculaire (RNA, qPCR, FACS).
• Intérêt pour les technologies transcriptomiques.
• Expérience en culture cellulaire est un plus.

Responsabilités

• Contribuer à un programme de recherche sur le cancer du pancréas.
• Mettre en œuvre des traitements expérimentaux sur des modèles in vitro.
• Collaborer avec des équipes bioinformatiques pour l'analyse des données.

Connaissances

Biologie moléculaire

Technologies transcriptomiques

Culture cellulaire

Rigueur

Travail d'équipe

Motivation pour la recherche translative

Formation

Master 2 en biologie ou ingénierie équivalente

Outils

Techniques de biologie moléculaire

SPLiT-seq

10x Genomics Visium

Description du poste

Biological sciences » Biological engineering

Organisation/Company INSERM U1068 Department Translata-it Research Field Biological sciences » Biological engineering Researcher Profile Other Profession Positions Research Support Positions Country France Application Deadline 31 Jul 2025 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jul 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

As part of an ambitious project funded by the ARC Foundation, we are looking for a molecular biology and transcriptomics research engineer to join our translational research team specializing in pancreatic cancer.

Your mission:
Contribute to a cutting-edge research program combining spatial transcriptomics, single-cell RNA sequencing, tumor organoids, and clonal tracing, with the goal of understanding how tumors resist treatment and identifying new therapeutic strategies.

Where to apply

E-mail [e-mail]

Requirements

Research Field Biological sciences » Biological engineering Education Level Undergraduate

Skills/Qualifications

Your skills:
• Strong experience in molecular biology (RNA, qPCR, FACS…)
• Interest in single-cell and spatial transcriptomic technologies
• Hands-on experience in cell culture and a collaborative mindset
• Rigor, organization, and strong motivation for patient-oriented research

Specific Requirements

• Educational Background
  • Master 2 degree or equivalent engineering degree in biology, biotechnology, or closely related fields.
• Technical Skills
  • Proven expertise in molecular biology techniques: RNA extraction, RT-qPCR, FACS, cell culture.
  • This experience is not mandatory, but will be considered an asset, particularly in the context of preparing tissue sections and samples for spatial transcriptomics platforms such as 10x Genomics Visium or Xenium.
  • Familiarity with single-cell RNA-seq workflows, especially SPLiT-seq, is a plus.
  • Experience in 3D culture systems, including tumor organoids and CAF co-cultures, is highly desirable.
  • Previous use of viral transduction methods for clonal tracing (e.g., barcoding) is appreciated.
• Project Involvement
  • Ability to follow and implement experimental chemotherapy treatments on in vitro models.
  • Participation in the coordination of biological samples with technical platforms (ICEP, DISC at CRCM).
  • Capacity to closely collaborate with bioinformatics teams for data analysis and experimental planning.
• Soft Skills
  • Strong organizational skills and experimental rigor.
  • Team-oriented mindset and ability to communicate across disciplines.
  • Strong motivation for translational research and interest in clinical applications.
• Additional Assets
  • Previous experience in translational cancer research projects.
  • Comfort working in a multidisciplinary environment at the interface of biology, technology, and clinical research.
  • Proficiency in French or English (minimum working knowledge of both is recommended).

Languages ENGLISH

Research Field Biological sciences » Biological engineering Years of Research Experience 1 - 4