Principal Clinical Scientist

Alignerr; France; Remote; EUR 90,000 - 131,000; Part time

Job summary

Alignerr seeks a Principal Clinical Scientist (AI Training) to bring senior clinical trial expertise into the development of regulator-ready AI training data. The role is fully remote as an hourly contract, requiring deep regulatory knowledge and the ability to shape how AI reasons about clinical evidence.

You will design protocols, review trial results, and ensure alignment with FDA/EMA expectations, while providing expert feedback to AI teams.

Qualifications

• Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission.
• Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent).
• Strong command of clinical research methodology and biostatistics.

Responsibilities

• Design and review clinical trial protocols for regulator-ready training datasets for AI systems.
• Interpret and audit clinical trial results for accuracy and regulatory relevance.
• Evaluate AI-generated clinical analyses for scientific soundness and regulatory alignment.
• Provide expert feedback shaping how AI models reason about trial data and outcomes.
• Flag gaps or misalignments in AI outputs with regulatory expectations.
• Work independently and asynchronously on a flexible schedule.

Skills

Clinical trial protocols

Regulatory interpretation (FDA/EMA)

Biostatistics

Translational science

Regulatory submissions (INDs/NDAs/CTDs

Job description

Principal Clinical Scientist (AI Training)

About The Role

What if your years of clinical trial expertise could directly influence how AI reasons about medical evidence, patient outcomes, and regulatory science? We're looking for a Principal Clinical Scientist to bring senior-level clinical knowledge into the development of cutting-edge AI systems — helping ensure the models shaping the future of biomedical research actually get the science right.

This is a fully remote, flexible contract role built for experienced clinical scientists who want to do meaningful work on their own terms. No AI background needed — just deep expertise in clinical research and regulatory standards.

• Organization: Alignerr
• Type: Hourly Contract
• Location: Remote
• Commitment: 10–40 hours/week

What You'll Do

• Design and review clinical trial protocols used to generate high-quality, regulator-ready training datasets for AI systems
• Interpret and audit clinical trial results to ensure accuracy, consistency, and regulatory relevance
• Evaluate AI-generated clinical analyses for scientific soundness and alignment with FDA, EMA, or equivalent regulatory expectations
• Provide expert feedback that directly shapes how AI models reason about clinical trial data, study design, and real-world outcomes
• Flag methodological gaps, statistical inconsistencies, or regulatory misalignments in AI outputs
• Work independently and asynchronously — on your schedule, at your pace

Who You Are

• Senior clinical scientist with hands-on experience designing clinical trial protocols for regulatory submission
• Deep expertise interpreting clinical data for major regulatory agencies (FDA, EMA, or equivalent)
• Strong command of clinical research methodology, biostatistics, or translational science
• Rigorous, detail-oriented, and confident making complex scientific judgments
• Clear and precise written communicator who can document feedback systematically

Nice to Have

• Prior experience with data annotation, data quality review, or AI evaluation workflows
• Background in pharmacology, epidemiology, medical affairs, or health outcomes research
• Experience authoring or reviewing regulatory submissions (INDs, NDAs, CTDs, or similar)
• Familiarity with AI tools or clinical decision support systems as an end user

Why Join Us

• Work directly on frontier AI systems making an impact on clinical and biomedical research
• Fully remote and flexible — work when and where it suits you
• Freelance autonomy with the structure of meaningful, expert-level task-based work
• Influence how AI understands, evaluates, and communicates real-world clinical evidence
• Collaborate with world-leading AI research teams and labs
• Potential for ongoing work and contract extension as new projects launch