Postdoctoral Researcher Position Deciphering the role of endothelial microparticles in cardiova[...]

European Commission; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

Une opportunité de poste postdoctoral se présente au sein d'un projet de recherche sur la dysfonction cardiaque liée au sepsis bactérien. Le candidat retenu travaillera sur l'étude de la mort cellulaire dans un contexte d'infections bactériennes. Ce projet est financé pour 2 ans et le salaire sera conforme aux règlements de l'INSERM.

Qualifications

• PhD requis dans un domaine pertinent.
• Expérience requise dans des modèles de souris et expérimentations in vitro.
• Motivation et dossier de recherche de haute qualité nécessaire.

Responsabilités

• Étudier la mort et la dysfonction des cardiomyocytes dans le contexte du sepsis.
• Identifier les facteurs libérés par les cellules endothéliales lors d'infections.
• Définir l'impact moléculaire et cellulaire de l'infection meningococcique.

Connaissances

Cardiac physiology

Bacteria associated sepsis

Mouse and in vitro models

Research skills

Formation

PhD in Cardiac physiology or related field

Description du poste

Organisation/Company INSERM Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country France Application Deadline 30 Jun 2025 - 12:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 38.5 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

About the project

Sepsis is a severe form of organ dysfunction, with high morbidity and mortality rates, worldwide. Cardiac dysfunction is one of the most common and severe complications of sepsis and directly affects patient mortality, as normal cardiac function is crucial for adequate organ perfusion. How sepsis induces acute cardiomyopathy is complex and characterized by numerous inter- and intra-cellular dysfunctions. The underlying mechanisms leading to cardiomyocyte acute dysfunction in the context of sepsis remains largely elusive. With the emergence of antibiotic-resistant bacteria, the number of individuals affected by bacteria-induced sepsis is bound to increase dramatically, representing an unmet medical need.

The overall objective of our project is to better understand cardiomyocyte death and/or dysfunction and therefore acute cardiac insufficiency in the context of bacterial sepsis, with a focus on N. meningitidis infection. For this, we leverage a consortium expertise in microbiology, vascular biology, cardiac biology, and critical care medicine.

Our main objectives are:(1) to identify factors specifically released by endothelial cells during meningococcal infection that will be involved in lethal sepsis. Will focus on endothelium-derived extracellular vesicles produced as a result of N. meningitidis interaction with endothelial cells, a specific feature of this infection; (2) to define the molecular and cellular impact of meningococcal infection on vascular and cardiac dysfunction, which ultimately leads to animal death.

Research keywords: Cardiovascular Dysfunctions; Endothelium-Derived Microparticles; Host-Pathogen Interactions; Sepsis; Mouse models

Where to apply

E-mail [e-mail]

Requirements

Research Field Biological sciences » Biology Education Level PhD or equivalent

Skills/Qualifications

Your profile

The applicant should be a highly motivated postdoctoral candidate with a PhD degree in “Cardiac physiology” or “Bacteria associated sepsis and mouse physiology” and a high-quality track record. He/she should have a strong background in performing research in mouse and in vitro models.

Languages ENGLISH Level Good

Languages FRENCH Level Good

Research Field Biological sciences Years of Research Experience None

Internal Application form(s) needed

Postdoc position - INEM - Cardiac dysfunction and Sepsis V2.pdf

The position is funded for 2 years (1+1). Salary will be according to experience following INSERM regulation.