Postdoctoral Researcher Midkine Alveolar Regeneration and Pulmonary Emphysema - IMRB INSERM

Campus des Métiers et des Qualifications; Créteil; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Un établissement de recherche de renom cherche un chercheur postdoctoral pour un projet sur la sénescence cellulaire et ses implications dans la biologie pulmonaire. Le candidat retenu travaillera sur l'isolement de fibroblastes et l'évaluation de la régénération alvéolaire, avec accès à des outils de biologie cellulaire avancés. Ce poste offre l'opportunité d'acquérir une expertise spécialisée dans un domaine en pleine expansion.

Qualifications

• Compétences en biologie cellulaire, moléculaire et biophysique indispensables.
• Expérience en culture de cellules primaires recommandée.
• La supervision d'étudiants de premier cycle peut faire partie des responsabilités.

Responsabilités

• Isoler des fibroblastes pulmonaires à partir de biopsies.
• Analyser l'effet de midkine sur les capacités de régénération alvéolaire.
• Superviser des étudiants de premier cycle selon les besoins.

Connaissances

Biologie cellulaire

Biologie moléculaire

Biochimie

Culture de cellules primaires

Culture d'organoïdes

Rigueur

Travail en équipe

Formation

Doctorat en biologie cellulaire ou domaine similaire

Description du poste

COPD, pathology induced by cigarette smoke, is characterized by airway remodeling and destruction of alveolar walls (emphysema), resulting in a reduction of the alveolar exchange surface and leading to chronic respiratory failure. Currently, no curative treatment exists. The lack of repair in emphysema is questioned, and why alveolar progenitors are not able to repair remains to be determined. Excessive lung senescence is emerging as a key cellular process that negatively impacts repair via their secretome. In this context, the team is recruiting a postdoctoral researcher on a 1-year contract to study the role of midkine secreted by senescent fibroblasts on the alveolar stem cell niche.

Our hypothesis is that cigarette smoke induces senescence in cells of the stem cell niche, which could act on lung fibroblasts via their secretome, especially midkine, leading to induction of senescence and altering the regenerative capacity of alveolar progenitor cells.

The recruited researcher will participate in isolating lung fibroblasts from patient biopsies and characterizing senescence induced by midkine. They will also assess the effect of midkine on alveolar regenerative capacities using alveolar organoids. The candidate will have access to cellular, molecular biology, and biochemistry tools, as well as platforms and expertise from university hospital researchers. This research project is funded by IRESP.

APPLICATION / RECRUITMENT / CONTACT PROCEDURE :

Send your CV, application letter, and contact details to [e-mail] as soon as possible, before September 15. An interview will be offered to shortlisted candidates. Recruitment is planned for October 2025.

Candidates should hold a PhD with skills in cell biology, molecular biology, and biochemistry. Experience in primary cell culture is recommended, and skills in organoid culture are a plus. Rigor and teamwork skills are essential. In addition to research, the candidate may supervise undergraduate students. This project offers the opportunity to acquire specialized expertise in pulmonary biology and senescence.