Job offer

European Commission; France; Sur place; EUR 33 000 - 45 000; Plein temps

Résumé du poste

Un laboratoire de recherche cherche un chercheur postdoctoral pour un projet multidisciplinaire sur la chimie et la biologie, portant sur le développement d'outils chimiques pour étudier et surmonter la chimiorésistance associée à la réparation de l'ADN dans les cancers. Des compétences solides en chimie organique et en techniques biochimiques sont exigées.

Qualifications

• Expérience solide en chimie organique, de préférence en chimie hétérocyclique.
• Compétence dans les techniques de caractérisation moléculaire (NMR, MS, HPLC).
• Connaissances en photophysique moléculaire et techniques biochimiques.

Responsabilités

• Développement de sondes fluorescentes pour étudier l'activité enzymatique des réparateurs d'ADN.
• Tests d'applications in vitro et dans des cultures cellulaires.
• Suivi des réglementations de santé et sécurité.

Connaissances

Chimie organique

Techniques de caractérisation moléculaire

Techniques biochimiques

Culture cellulaire

Microscopie à fluorescence

Anglais (lu, écrit, parlé)

Organisational skills

Description du poste

Organisation/Company CNRS Department Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques Research Field Chemistry Biological sciences Pharmacological sciences Researcher Profile Recognised Researcher (R2) Country France Application Deadline 26 Jun 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The postdoctoral researcher will be involved in a multidisciplinary research project aimed at developing fluorescent probes for the enzymatic activity of one of the DNA repair enzymes involved in cancer chemoresistance, and testing their applications in vitro and in cell cultures.

Organic synthesis.
Absorbance and fluorescence spectroscopy.
Biochemical studies (electrophoresis gels, enzymatic assays).
Cell culture and fluorescence microscopy.

The host team, “New Synthetic Methods for the Chemistry–Biology Interface,” is part of the CNRS UMR8601 unit, “Laboratory of Pharmacological and Toxicological Chemistry and Biochemistry,” located at Université Paris Cité (Paris 6th arrondissement). The team's research interests span a wide range of topics in synthetic organic chemistry and chemical biology, all rooted in molecular innovation. Our work involves exploring new chemical spaces and developing synthetic tools or analytical methods to study and/or modulate biological regulatory mechanisms.

The proposed position is part of a multidisciplinary project funded by AVIESAN, focused on developing chemical tools to study and overcome chemoresistance linked to DNA repair in cancers. This project is conducted in collaboration with teams at Université Paris-Saclay (Orsay) and the Institut du Cerveau (Paris).

- Strong experience in organic chemistry, preferably in heterocyclic chemistry or nitrogenous base analogs.
- Proficiency in molecular characterization techniques (NMR, MS, HPLC, UV/Vis, fluorescence).
- Solid knowledge of molecular photophysics.
- Strong experience in biochemical techniques: electrophoresis gels, enzymatic assays.
- Hands-on experience with cell culture (cancer cells) and fluorescence microscopy.
- Organizational and adaptability skills.
- Excellent command of English (reading, listening, and writing protocols and articles).
- Monitoring of health and safety regulations and ensuring their implementation in collaboration with the Prevention Assistant.

Additional comments

Applications must be submitted through the CNRS portal. Applications received by email will not be considered.