Postdoctoral Position in Oncology (M / F)

Institut Curie; Paris; Sur place; EUR 35 000 - 55 000; Plein temps

Résumé du poste

Un acteur majeur dans la recherche contre le cancer recherche un postdoctorant passionné pour rejoindre une équipe dynamique. Ce rôle implique d'explorer les mécanismes de régulation de la protéine EWSR1 : : FLI1 et de collaborer à des projets innovants pour développer des thérapies pour les enfants atteints de cancers solides. En intégrant un environnement riche en culture et en science, vous aurez l'opportunité de contribuer à des recherches de pointe tout en travaillant avec des experts dans le domaine. Si vous êtes motivé par l'innovation et la résolution de problèmes, cette position est faite pour vous.

Prestations

Restauration collective

Remboursement des frais de transport jusqu'à 70%

Assurance santé complémentaire

Qualifications

• PhD requis en biologie moléculaire ou biotechnologie.
• Connaissances solides en oncologie et biologie cellulaire.

Responsabilités

• Étudier la régulation de la stabilité de la protéine EWSR1 : : FLI1.
• Collaborer avec des équipes de biologie chimique pour identifier des stratégies thérapeutiques.

Connaissances

Biologie moléculaire

Biologie cellulaire

Oncologie

Biologie chimique

Anglais

Analyse scientifique

Esprit d'équipe

Formation

PhD en biologie moléculaire ou biotechnologie

Description du poste

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital Group and a Research Center of more than 1000 employees with a strong international objective. The Research Center aims to develop basic research and use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient. It is located in the center of Paris in France, in a culturally and scientifically rich environment. The site has an active seminar program and hosts regular training sessions in various Life Science topics including molecular and cellular biology, immunology, chemistry, and computational biology. It hosts the world-class SIREDO Oncopediatric Center which gathers research and clinical activities.

Laboratory & Project

The research group of Olivier Delattre is a partner of the KOODAC Cancer Grand Challenge project, which gathers pediatric cancer biology and chemical biology research teams to deliver transformative new therapies for children with solid malignancies driven by oncoproteins. The Delattre group has pioneered the discovery and functional characterization of the EWSR1 : : FLI1 oncoprotein of Ewing sarcoma. It has shown that the viability of Ewing cells requires a precise range of EWSR1 : : FLI1 expression and activity. The postdoc will investigate the mechanisms of the regulation of EWSR1 : : FLI1 protein stability and collaborate with chemical biology teams of the KOODAC program to identify therapeutic strategies to degrade or stabilize this protein to induce toxicity on Ewing cells.

Constraints and Risks

• Use of biological / chemical products

Training and Skills Required

• Candidate should hold a PhD in molecular and cellular biology, or biotechnology.
• The candidate should have good knowledge in oncology as well as in molecular and cellular biology.
• Expertise in protein biochemistry would be a plus.
• Good proficiency in English.
• Scientific rigor and excellent analytical and synthetic capabilities.
• Team spirit and dynamic personality with a passion for innovation and problem-solving.

Abilities

• Ability to work independently, managerial abilities, aptitude for working in a team.
• The candidate should be highly motivated, curious, and enthusiastic to work in a collaborative team.

All our opportunities are open to people with disabilities.

Contract Information

Type of Contract: Fixed-term contract (COD)

Starting Date: As soon as possible

Duration: 18 months (renewable contract up to 3 years)

Working Time: Full time

Remuneration: According to the current grids

Benefits: Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Location of the Position: Paris, 5eme

Reference: NA

Contact

Please send your CV, letter of motivation, and 3 references.

CVs will be processed on the go; therefore, the position could be filled before the deadline for applications.

Institut Curie is an inclusive, equal opportunity employer and is dedicated to the highest standards of research integrity.