Postdoctoral Position in Mammalian DSB Repair (F/M)

European Commission; France; Sur place; EUR 20 000 - 40 000; Plein temps

Résumé du poste

A leading research institution in France is seeking a Postdoctoral Fellow to study molecular mechanisms of double-strand break (DSB) repair in human cells. The ideal candidate has a strong interest in DNA repair and chromosome biology, a PhD in related fields, and at least one publication as first author. This full-time position offers a dynamic research environment with competitive remuneration and benefits, starting from October 15, 2025.

Prestations

Collective catering

Transportation fee reimbursement up to 70%

Supplementary health insurance

Qualifications

• Strong experience in manipulating human cell lines is ideal.
• Publication as first author is necessary.
• Candidates should be fluent in English.

Responsabilités

• Study molecular mechanisms of DSB repair in human cells.
• Use innovative genome editing approaches.
• Collaborate with team members and the laboratory.

Connaissances

DNA repair

Chromosome biology

Fluent in English

Manipulating human cell lines

Formation

PhD degree in related fields

Description du poste

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Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country France Application Deadline 30 Sep 2025 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Offer Starting Date 15 Oct 2025 Is the job funded through the EU Research Framework Programme? Horizon 2020 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Institut Curie is a major player in the research and fight against cancer. It consists of a Hospital group and a Research Center of more than 1000 employees with a strong international representativeness.

The objective of the Research Center is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Laboratory

The successful candidate (F/M) will join Valérie Borde's team belonging to the Institut Curie Research Center and affiliated to the Nuclear Dynamics and Dynamics of Genetic Information departments.

The Institut Curie is a highly vibrant research center, offering an international and multidisciplinary research environment in central Paris.

The Chromosome Dynamics and Recombination team led by Valérie Borde, studies the mechanisms involved in the repair of double-strand breaks during meiosis and somatic growth, combining cutting-edge genomics, proteomics and molecular biology technologies ( https://institut-curie.org/team/borde ). It is a highly dynamic international group currently including 2 PhD students, 1 post-doc, 4 engineers and 2 staff scientists. In addition to in-house scientific and technical skills provided by team members, the post-doctoral fellow will benefit from the stimulating and collaborative environment of the Institut Curie Research Center and from its cutting-edge technological platforms.

Nicolas, Y., Bret, H., Cannavo, E., Acharya, A., Cejka, P.#, Borde, V.# and Guérois, R.# (2024) “Molecular insights into the activation of Mre11-Rad50 endonuclease activity by Sae2/CtIP.” Molecular Cell 84 , 2223-2237.

Pyatnitskaya, A., Andreani, J., Guérois, R., De Muyt, A. and Borde, V. (2022) The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly. Genes and Development 36 , 53-69.

Cohen, S., Guenolé, A., Lazar, I., Marnef, A., Clouaire, T., Vernekar, D., Puget, N., Rocher, V., Arnould, C., Aguirrebengoa, M., Genais, M., Firmin, N., Shamanna, R., Mourad, R., Bohr, W., Borde, V. and Legube, G. (2022) A POLD3/BLM dependent pathway handles DSBs in transcribed chromatin upon excessive RNA:DNA hybrids accumulation. Nature Communications 13 , 2012 .

The project

This exciting project will focus on the study of the molecular mechanisms of DSB repair in normal and recombination-deficient human cells at defined genomic locations to explore different genomic contexts. The post-doc will use innovative unpublished genomic approaches in combination with genetic, molecular and genome editing approaches. The project will be made with the support from Institut Curie genomic facilities, and from an engineer in the lab for computational analyses.

Candidate Profile

Training and Skills required

• Training: We invite applications from candidates with a strong interest in DNA repair and chromosome biology, and a strong experience in manipulating human cell lines. Ideally (but not mandatory) with a mixed background in molecular biology and computational analyses of genomic data.
• Scientific skills: Candidates holding, or shortly expecting to be awarded, a PhD degree in related fields are encouraged to apply.
• Applicants should have at least one publication as first author.
• Language skills: Candidates should be fluent in English, which is the language used in the lab.

Abilities

• H ighly self-motivated
• Rigorous
• Creativity, ability to work independently and to collaborate with others

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract.

Starting date: from October 15th 2025

Duration: initial 12 months will be provided but the candidate should be competitive to apply for postdoctoral fellowships.

Working time: full time

Remuneration: according to the current grids

Benefits : Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.