Postdoctoral Position in Cancer Biology (M/F)

European Commission; France; Sur place; EUR 30 000 - 45 000; Plein temps

Résumé du poste

L'Institut Curie recherche un postdoc pour étudier le rôle du microbiote intratumoral dans les réponses thérapeutiques. Le candidat devra travailler au sein d'une équipe internationale sur des modèles innovants, participant aux analyses cellulaires et à la gestion des collaborations. Une solide formation en biologie cellulaire ainsi que des compétences en culture de cellules et biologie moléculaire sont indispensables.

Prestations

Restauration collective

Remboursement des frais de transport jusqu'à 70%

Assurance santé complémentaire

Qualifications

• Solide formation en biologie cellulaire ou immuno-oncologie.
• Compétences requises en culture cellulaire, microscopie et biologie moléculaire.
• Capacité à travailler de manière autonome et en équipe.

Responsabilités

• Isolation de cellules autologues primaires à partir d'échantillons tumoraux frais.
• Génération de modèles tumoraux sur chip à partir de bactéries résidentes aux tumeurs.
• Traitements médicamenteux des modèles tumoraux et analyse.

Connaissances

Culture cellulaire mammifère

Microscopie et analyse d'images cellulaires

Biologie moléculaire

Fluency in English

Formation

Formation solide en biologie cellulaire du cancer ou immuno-oncologie

Description du poste

Organisation/Company Institut Curie - Research Center Department Administration Research Field Medical sciences » Cancer research Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country France Application Deadline 1 Sep 2025 - 09:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Offer Starting Date 13 Jun 2025 Is the job funded through the EU Research Framework Programme? Horizon 2020 Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The hosting structure

The Curie Institute Research Center

The Institut Curie is a major player in the research and fight against cancer. It consists of a hospital and a Research Centre of more than 1000 employees with a strong international representativeness.

The objective of the Curie Institute Research Centre is to develop basic research and to use the knowledge produced to improve the diagnosis, prognosis, and therapeutics of cancers as part of the continuum between basic research and innovation serving the patient.

Context

Laboratory

"Chemical Biology of Cancer" Unit - Director: Fatima Mechta-Grigoriou

“Stress and Cancer” Laboratory - Director: Fatima Mechta-Grigoriou

Project funded by European Commission, in the context of the Horizon Europe program, Mission Cancer 2023.

International collaboration between Institut Curie and Assistance Publique Hôpitaux de Paris - Bichat hospital (France), Universidade Catolica Portugueasa (Portugal), University of Rome TorVergata and Humanitas University in Milan (Italy).

Title: Assessing the role of intratumoral microbiota in therapy responses using patient-derived tumor-on-chip

Resistance to therapies is a major challenge in oncology. Recent research suggests that intratumoral microbiota may contribute to anti-cancer drug resistance, in particular to immunotherapies. Indeed, tumors are colonized by numerous microorganisms, bacteria, viruses, fungi, which should be considered as novel important players of the tumor ecosystems. However, experimental approaches to address the role of microbiota in human cancers are lacking. This problem will be tackled by using an innovative state-of-the-art 3D tumor-on-chip (ToC) model, as part of the emerging field of Micro-Physiological Systems (MPS).

Project ARTURO aims to decipher the role of patient-derived bacteria, and of their postbiotics and released extra-cellular vesicles, in tumor ecosystem behaviors and drug responses, by integrating clinical data, omics analysis, and novel ToC-based information (live imaging and single-cell transcriptomics). The focus will be on two frequent poorly-understood cancer subtypes: non-small cell lung cancer (NSCLC) and invasive lobular breast cancer (ILC).

In this context, the team “Stress and Cancer” is opening a postdoctoral position. T he applicant is expected to participate the activities of the project ARTURO with the following responsibilities : i) isolation of primary autologous cells from fresh tumor samples (cancer and immune cells, cancer-associated fibroblasts); ii) generation of patient-derived ToC integrating newly identified tumor-resident bacteria; iii) drug treatments of ToC and analysis (cell imaging, transcriptomics); iv) liaison with collaborators, clinicians, computer scientists, and platforms.

Project results are expected to provide a deep understanding of processes underlying tumor-host interactions and to help the conception of novel microbiota-based intervention strategies.

1. Bioengineering a patient-derived vascularized lung tumor-on-chip model to decipher immunomodulation by the endothelium. Lansche & Ladaigue et al, Adv Healthc Mater. 2025May 9:e2403446. doi: 10.1002/adhm.202403446.

2. Assessing personalized responses to anti-PD-1 treatment using patient-derived lung tumor-on-chip. Veith & Nurmik et al, Cell Rep Med 2024, May 21;5(5):101549. doi: 10.1016/j.xcrm.2024.101549.

3. Sensitizing cancer cells to immune checkpoint inhibitors by microbiota-mediated upregulation of HLA class I. Ferrari et al, Cancer Cell 2023, Oct 9;41(10):1717-1730.e4. doi: 10.1016/j.ccell.2023.08.014. Epub 2023 Sep 21.

Candidate Profile

Training:

• Solid background in cancer cell biology or immuno-oncology.

Required skills:

• Mammalian cell culture
• Microscopy and cell image analysis
• Bases of cellular biochemistry (flow cytometry, immunofluorescence staining, etc.) and molecular biology (DNA/RNA extraction, sequencing, etc.)
• Fluency in English

Desired skills:

• Working with human primary cells
• Bacterial cultures
• Transcriptomic analysis
• Microphysiological systems (organ-on-chip)

Abilities

• Autonomy
• Self-motivation
• Organizational capacity
• Aptitude for working in a team

All our opportunities are open to people with disabilities

Contract information

Type of contract: Fixed-term contract.

Starting date: September or October 2025

Duration: 18 months

Working time: full time

Remuneration: according to the current grids

Benefits : Collective catering, reimbursement of transportation fees up to 70%, supplementary health insurance

Institut Curie is an inclusive, equal opportunity employer

and is dedicated to the highest standards of research integrity.