Postdoctoral Organic / Medicinal Chemist

You will be part of the Marquez Team at EMBL Grenoble and work at the CSCF Chemistry lab in EMBL Heidelberg. You will contribute to the design, synthesis and optimization of novel bioactive compounds starting from fragment screening hits identified through the high throughput crystallography pipelines at the HTX facility in Grenoble. Your duties will include:

• Design and synthesize new bioactive compounds for various target proteins/receptors in medicinal chemistry and agrochemistry.
• Collaborate closely with Computational Chemistry, X-ray Crystallography, in vitro and in vivo screening experts.
• Design, conduct and optimize multi-step syntheses as required by project needs.
• Monitor reactions and characterize the products using standard analytical methods (TLC, HPLC, HPLC-MS and NMR).
• Evaluate both chemical and biological results and define routes for compound optimization.
• Maintain accurate documentation of procedures and results according to laboratory’s guidelines.
• Report results in internal meetings.
• Contribute to conceptual planning and monitoring of project progress.
• Mentor Ph.D. and Masters students working in the lab.
• Contribute to the smooth operation and maintenance of lab infrastructure and equipment.
• Adhere to health and safety requirements.

Grading: Stipend

Reference number: GR00232

You have:

We seek a motivated person with relevant scientific and technical expertise ready to learn and take ownership and responsibility for the tasks. The ideal candidate would have:

• A degree in organic chemistry, chemical biology or medicinal chemistry. Postdoctoral experience would be preferred.
• Profound experience in organic syntheses and analytical techniques.
• Experience in the design and synthesis of biologically active molecules.
• Ability to work productively in an interdisciplinary team environment.
• Excellent presentation skills and ability to communicate effectively in cross-functional teams.
• Experience with standard software packages, search engines and scientific databases is expected.

The successful candidate is a motivated self-starter with a proven ability to work within a multidisciplinary team environment and ready to travel regularly to Grenoble and within Europe. The candidate needs to have strong communication and organizational skills. A high standard of written and spoken English is mandatory.

You might also have:

Experience in computational chemistry and modelling.