Postdoctoral Fellow: Single-Cell Immunology in Paris

Institut Imagine; Paris; Hybride; EUR 42 000 - 56 000; Plein temps

Avantages offerts par ce poste

Competitive salary

Career development

Live in Paris

Résumé du poste

Institut Imagine in Paris seeks a highly motivated postdoctoral researcher to join the SMART-JIA project, validating predictive biomarkers of anti-TNF non-response in JIA and adult RA. The role combines single-cell multi-omics, functional immunology, and translational approaches to define TNF-independent inflammatory endotypes.

You will work with patient-derived PBMCs, develop ex vivo assays, and contribute to the SMART-Score algorithm with clinical collaborators across pediatric and adult

Qualifications

• PhD in Immunology, Cell Biology, Molecular Biology, or related discipline.
• Strong expertise in flow cytometry/cell sorting and functional immunology assays.
• Experience with primary human immune cells, ideally from clinical cohorts.
• Familiarity with single-cell omics technologies (10x Genomics) and/or epigenetic approaches.
• Ability to work independently in a collaborative, translational research environment.
• Excellent scientific communication skills (written and oral, in English).

Responsabilités

• Design, perform, and analyze single-cell multi-omics experiments (10x Genomics Multiome, scRNA-seq, scATAC-seq) from patient-derived PBMCs.
• Develop and execute ex vivo functional assays to investigate molecular mechanisms of treatment resistance.
• Perform computational analyses of single-cell datasets, or collaborate closely with bioinformaticians.
• Contribute to biomarker validation and development of the SMART-Score predictive algorithm with clinical collaborators.

Connaissances

Flow cytometry

Cell sorting

Single-cell omics

Biomarker validation

Collaborative work

Formation

PhD in Immunology or related

Outils

10x Genomics Multiome

scRNA-seq

scATAC-seq

Description du poste

Institut Imagine in Paris seeks a highly motivated postdoctoral researcher to join the SMART-JIA project, validating predictive biomarkers of anti-TNF non-response in JIA and adult RA. The role combines single-cell multi-omics, functional immunology, and translational approaches to define TNF-independent inflammatory endotypes.

You will work with patient-derived PBMCs, develop ex vivo assays, and contribute to the SMART-Score algorithm with clinical collaborators across pediatric and adult