Postdoctoral Position - HIV 1 Innate Sensing (F/M)

Institut Imagine; Paris; Hybride; EUR 40 000 - 60 000; Plein temps

Avantages offerts par ce poste

Mentoring and career development

Conference attendance support

BSL-3 access

International research environment

Résumé du poste

Institut Imagine in Paris invites applications for a postdoctoral project on lipid metabolism, innate sensing of HIV-1, and dendritic cell pathways. The successful candidate will explore how lipid metabolic pathways regulate antiviral immunity using lipidomics, scRNA-seq, and scATAC-seq in human dendritic cells.

The project offers access to world-class platforms, mentorship, and opportunities to present at international conferences within a vibrant research environment.

Qualifications

• PhD in immunology or a closely related field.
• Experience with lipidomics and single-cell omics is preferred.
• Strong written and oral communication in English; ability to work in an international team.

Responsabilités

• Characterize HIV-1–induced lipid metabolism changes in human dendritic cells.
• Investigate how lipid metabolism modulates HIV-1 replication and innate sensing.
• Apply lipidomics, scRNA-seq, and scATAC-seq to study antiviral immunity.
• Collaborate with bioinformatics for systems biology analyses.

Connaissances

Lipid metabolism

Dendritic cells

Interferon signaling

Formation

PhD in immunology or related field

Outils

Lipidomics

scRNA-seq

scATAC-seq

Systems biology

Description du poste

The SCInflaNet laboratory, led by Dr. Mickaël Ménager, investigates the molecular mechanisms controlling inflammatory responses using advanced single-cell and multi-omics approaches.

https://www.institutimagine.org/en/mickael-menager-187

Research Project: Lipid Metabolism, Innate Sensing of HIV-1, and Pathways Engaged by Dendritic Cells

Dendritic cells (DCs) are critical sensors of viral infection and orchestrators of adaptive immunity. However, HIV-1 has evolved mechanisms that largely evade detection by these cells, limiting antiviral immune responses and facilitating viral spread.

Recent work from our laboratory identified an unexpected link between HIV-1 infection, lipid metabolism and type I interferon production in dendritic cells. Building on these findings, this postdoctoral project aims to uncover how lipid metabolic pathways regulate HIV-1 sensing and antiviral immunity.

The successful candidate will:

• Characterize HIV-1-induced alterations in lipid metabolism and lipid-mediated signaling pathways in human dendritic cells.

• Investigate how lipid metabolism influences:

  • HIV-1 replication,

  • innate viral sensing mechanisms,

  • type I interferon responses.

• Employ cutting-edge approaches including:

  • lipidomics,

  • scRNA-seq,

  • scATAC-seq,

  • systems biology and computational analyses.

What we offer:

• A vibrant and international research environment at Institut Imagine.

• Access to world-class technological platforms, including:

  • Single-cell genomics,

  • Flow cytometry,

  • Advanced imaging,

  • Bioinformatics support,

  • BSL-3 facilities.

• Strong mentoring and career development opportunities.

• Support for conference attendance, networking, and grant‑writing activities.

• Competitive salary according to institutional scales.

• The opportunity to live and work in Paris, one of Europe’s leading scientific hubs.