Job offer

European Commission; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

A leading research team at the European Commission seeks highly skilled Postdoctoral Fellows to explore the roles of long non-coding RNA in immune regulation and therapy response. The position offers a dynamic, interdisciplinary environment at one of France's premier research centers, focusing on innovative strategies to enhance patient outcomes in kidney cancer.

Prestations

Access to advanced scientific services

Engage with an international research team

State-of-the-art technological platforms

Qualifications

• Ph.D. in a related field required.
• Strong background in molecular biology and immunology essential.
• Experience with molecular biology techniques and data analysis is a must.

Responsabilités

• Design and perform molecular biology assays in vitro and in vivo.
• Conduct experiments to study long non-coding RNA roles in immune response.
• Collaborate with bioinformaticians to analyze various genomic datasets.

Connaissances

Molecular Biology

Biochemical Analysis

Immunology

Long Non-coding RNA

Formation

Ph.D. in Biology, Chemistry, or Immunology

Outils

Genome Editing

Description du poste

Organisation/Company CERBM Research Field Biological sciences » Biology Researcher Profile First Stage Researcher (R1) Positions Postdoc Positions Country France Application Deadline 1 Jul 2025 - 00:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 36h15 Offer Starting Date 1 Sep 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Join Malouf Team at the Institute of Genetics and Molecular and Cellular Biology (Illkirch, France) in an exciting opportunity to unravel the role of long non-coding RNA in immune regulation and response to immunotherapy. We are seeking highly skilled and motivated Postdoctoral Fellows with expertise in molecular biology to contribute to our international multidisciplinary team of molecular biologists, physician- scientists and bioinformaticians.

The Malouf Lab at IGBMC is dedicated to uncovering the genetic and epigenetic mechanisms underlying renal cell carcinomas, with a particular focus on rare and treatment-resistant subtypes. Our research combines functional genomics, epigenetics, and single-cell technologies to understand tumor heterogeneity and therapy response.
Our recent projects include the identification of biomarkers of response to immunotherapy using epigenetic profiling, bulk and single-cell RNA sequencing (RNA-seq and scRNA-seq), and spatial transcriptomics. We are particularly interested in how epigenetic alterations, the stromal microenvironment, and endogenous retroviruses (ERVs) influence treatment outcomes.
We have recently identified several long non-coding RNAs (lncRNAs) associated with response and resistance to therapy. Using gain- and loss-of-function studies, we have validated the critical roles of some of these lncRNAs in tumor biology. Our team is now investigating the molecular pathways through which these lncRNAs act, using integrated approaches that combine mechanistic studies in vitro and in vivo with analysis of patient-derived tumor samples, obtained through robust national and international collaborations.
Our ultimate goal is to generate discoveries that pave the way for innovative therapeutic strategies to improve the management and outcomes of patients with rare kidney cancers.

The project will be carried out at IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), one of the largest and most prestigious research centers in France. IGBMC is jointly operated by Inserm, CNRS, and the University of Strasbourg, and is internationally recognized for its leadership in functional genomics and biomedical research.

The institute offers a dynamic and interdisciplinary environment, bringing together expertise at the crossroads of biology, biochemistry, biophysics, and medicine. Researchers benefit from access to cutting-edge scientific services and state-of-the-art technological platforms, including genomics, imaging, proteomics, and animal facilities.

Located within the Parc d’Innovation in Illkirch, just south of Strasbourg, IGBMC is part of a vibrant scientific and innovation ecosystem that fosters collaborative research, technology transfer, and training of the next generation of biomedical scientists.

Where to apply

E-mail [e-mail]

Requirements

Research Field Biological sciences » Biology Education Level PhD or equivalent

Skills/Qualifications

Responsibilities:
• Design and perform molecular biology and biochemical assays using in vitro, cell culture, and in vivo models.
• Conduct gain-of-function experiments in mouse models to investigate the role of long non-coding RNAs (lncRNAs) in immune regulation and response to immunotherapy.
• Work in close collaboration with bioinformaticians to analyze genome-wide datasets, including single-cell, multi-omic, transcriptomic, and epigenetic profiles.

We Offer:
• Join a young and highly motivated international team
• Work in a collaborative, multidisciplinary environment with basic scientists, physician-scientists, and bioinformaticians
• Access state-of-the-art technologies and well-equipped modern technological platforms
• Engage in multifaceted and varied work, from experiments to applied bioinformatics
• Conduct basic science with clinical relevance

Specific Requirements

• A Ph.D. in a field related to biology, chemistry, or immunology
• Strong background in molecular biology, immunology, and long non-coding RNA
• Previous work experience in molecular biology and biochemical analysis
• Curriculum vitae with a publication list, a short summary of research achievements, and mastered techniques in English
• Fluency in English (written and spoken)

Preferential requirements:

• Experience in genome editing is a plus
• Experience in animal models is considered a strong asset but not required
• Ability to communicate the acquired results by writing manuscripts and giving presentations

Required personal skills:

• Proactivity
• Ability to work in a multidisciplinary team

Languages ENGLISH Level Excellent

Languages FRENCH Level Good

Additional Information

Selection process

How to Apply:
Candidates should send their application documents (in English) to Pr. Gabriel Malouf ([e-mail] ) as a single PDF including:

• A curriculum vitae with a publication list
• A short summary of research achievements, and mastered techniques in English.
• A motivation letter covering your education/scientific experiences and how they have prepared/motivated you to work on the role of long non-coding RNA in immune regulation (max 1 page)
• A description of how techniques used by the laboratory could have benefitted your PhD project or of a project in which you would like to employ such a label in the future (max 1 page). For this refer to the recent publications of the team (Vokshi et al. Nature Communications, 2023; Su et al. Nature Communications, 2023; Davidson et al. Cancer Research, 2023; Lu et al. Cell Reports Medicine, 2023; Helleux et a. Embo Molecular Medicine, 2025)
• The names and contacts of 2 referees with supporting letters/contact details
• The application deadline is July 1th 2025. The positions will be opened until filled. We are reviewing the applications as soon as they are received; candidates are strongly encouraged to apply as soon as their application fulfill the criteria above.

Additional comments

Start Date: September 2025
Duration: 3 years
Research Focus: Dissection of the role of long non-coding RNA in response to immunotherapy using functional genetics, in vitro and in vivo approaches