Postdoctoral fellow in structural biology (M/F)

European Commission; France; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

A leading research institute in France is seeking a candidate to study the structure and dynamics of large intrinsically disordered scaffold proteins. This position involves protein expression, purification, and structural analysis through NMR characterization and X-ray crystallography. Applicants should hold a Ph.D. in a relevant field and have experience with protein work. A B1 level of English is required.

Qualifications

• Demonstrated experience in protein expression and purification.
• Experience in structure determination by cryo-EM and/or X-ray crystallography.
• Knowledge of protein NMR spectroscopy is advantageous.

Responsabilités

• Study the structure and dynamics of intrinsically disordered scaffold proteins.
• Conduct expression and purification of proteins for analyses.
• Perform NMR characterization of scaffold protein interactions.
• Determine structure of kinase/scaffold protein complexes.

Connaissances

Protein expression and purification

NMR spectroscopy

X-ray crystallography

Cryo-electron microscopy

English (B1 level)

Formation

Ph.D. in chemistry, biochemistry, biophysics, or structural biology

Description du poste

Would you like to help us make EURAXESS even better? Take this very quick user satisfaction survey - it won’t take more than 5 minutes!

Organisation/Company CNRS Department Institut de biologie structurale Research Field Physics Researcher Profile Recognised Researcher (R2) Country France Application Deadline 21 Aug 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Nov 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The candidate will study the structure and dynamics of large intrinsically disordered scaffold proteins and their interactions with kinases from the mitogen-activated protein kinase (MAPK) cell signaling pathways.

- Expression and purification of proteins (E. coli/insect cells) for structural and biophysical analyses
- NMR characterization of intrinsically disordered regions of scaffold proteins and their interactions with kinases
- Biophysical analysis of protein-protein interactions
- Structure determination of kinase/scaffold protein complexes by X-ray crystallography or cryo-electron microscopy

Located on the Grenoble Science Park (ESRF/ILL/EMBL/IBS), the Institute of Structural Biology (IBS) is a national and international player in the field of integrated structural biology. The IBS is a research center, a technical platform, a host site and a scientific training center. Its mission is to develop research in structural biology, a field of research that is crucial to the understanding of fundamental biological mechanisms. It is supported by 12 state-of-the-art platforms.
As a joint research unit (CEA-CNRS-UGA), the IBS is composed of 20 research groups, each of which proposes a multi-disciplinary approach, at the frontiers of biology, physics and chemistry, in coherence with 3 research axes. Nearly 320 people work there as researchers, PhD students, engineers and technicians in a multicultural and international environment.
The candidate will join the group of Malene R. Jensen, which specializes in understanding the functional role of intrinsically disordered proteins in cellular signaling. The group also focuses on developing cutting-edge methodologies to characterize highly dynamic protein complexes.
More information at: www.jensen-nmr.fr

The ideal candidate holds a Ph.D. in chemistry, biochemistry, biophysics, or structural biology, and has demonstrated experience in protein expression and purification, as well as in structure determination by cryo-electron microscopy (cryo-EM) and/or X-ray crystallography. Knowledge of protein NMR spectroscopy would be an asset. A B1 level of English is required.