Postdoctoral fellow in Cytokine induced cell death

Servier; France; Hybrid; EUR 45,000 - 60,000; Full time

Benefits offered by this job

13th-month salary

27 days of paid leave

Flexible remote work options depending

On-site company restaurant

Job summary

Servier's R&D Institute at Paris-Saclay invites a postdoctoral researcher to investigate how colorectal cancer cells resist immune cytokine pressure and to identify approaches to enhance cytokine-induced tumor-cell killing. The project combines mechanistic biology, functional genomics and translational cancer models.

You will design and execute in vitro and in vivo experiments, review literature, present data, manage priorities, and collaborate within the Immuno-Oncology portfolio.

Qualifications

• PhD in a relevant biomedical field and strong background in cancer biology.
• Experience with oncology models or cytokine signaling is advantageous.
• Hands-on experience with organoids or patient-derived models is a plus.
• Excellent written and oral English required.

Responsibilities

• Design and conduct in vitro and in vivo experiments to advance the project.
• Analyze data and propose next steps.
• Review literature and integrate findings into decisions.
• Present progress at internal scientific and project meetings.
• Manage priorities, timelines and resources.
• Collaborate across Immuno-Oncology programs and share learnings.
• Identify and evaluate potential therapeutic targets.

Skills

Excellent written and oral English

Autonomous, proactive

Collaborative and innovative

Ability to drive a research project

Organize priorities

Education

PhD in cancer biology or related field

Tools

CRISPR-based perturbation or screening

Flow cytometry

Immunoblotting

Quantitative cell-based assays

Organoids or patient-derived models

Job description

We are a global and independent mid-sized pharmaceutical group governed by a Foundation. Our unique model makes us proud and, more importantly, enables us to fully serve our mission: "committed to therapeutic progress for the benefit of patients."

As a global leader in cardiology, we aim to become a focused and innovative player in oncology by 2030, targeting hard-to-treat cancers and dedicating more than 70% of our R&D budget to this goal.

Who are we? 20,000 passionate individuals from over 50 nationalities, driven by an entrepreneurial spirit. Every day, we move forward with and for patients, with and for our teams, motivated by the desire to care, to dare, to grow, and to commit to being useful to those in need.

Come and experience and contribute to our commitment #MovedByYou.

www.servier.com

About our R&D Institute in Paris Saclay

At the heart of one of the world's top eight innovation clusters, the Servier R&D Institute at Paris-Saclay is where visionary science meets a powerful global ecosystem. By uniting our Group's innovation potential with this prestigious center of excellence, we are not only accelerating the future of therapeutic discovery but also championing the global influence of French research.

This three-year postdoctoral position will investigate the mechanisms by which colorectal cancer cells resist immune cytokine pressure and identify approaches to enhance cytokine-induced tumor-cell killing. The project combines mechanistic biology, functional genomics and translational cancer models to characterize sensitivity and resistance mechanisms in IFN/TNF signaling and cell-death pathways, and to generate therapeutic and biomarker hypotheses with translational potential.

Main responsibilities

• 1. Design and execute relevant in vitro and in vivo experiments to advance the research project.
• 2. Analyze and interpret experimental data and recommend appropriate next steps.
• 3. Review scientific literature and integrate relevant findings into project decisions.
• 4. Present project progress and data in internal scientific and project meetings.
• 5. Manage priorities, timelines and resources to support efficient project execution.
• 6. Contribute to collaborative projects within the Immuno-Oncology portfolio and share learnings across programs.
• 7. Contribute to the identification and evaluation of potential therapeutic targets.

Profile

• PhD in cancer biology, tumor immunology, cell-death biology, molecular biology, functional genomics or a related discipline.
• Experience with oncology models and/or cytokine signaling is an advantage.
• Expertise in mammalian cell culture and quantitative cell-based assays.
• Experience with cancer cell models and with one or more of the following: CRISPR-based perturbation or screening, flow cytometry, immunoblotting, or analysis of signaling and cell-death pathways.
• Experience with organoids or patient-derived models is a plus.
• Excellent written and oral English.
• Ability to drive a research project with scientific independence, organize priorities, collaborate effectively in multidisciplinary teams, and communicate results clearly to scientific and project stakeholders.
• Autonomous, proactive, rigorous, collaborative and innovative.

Our standard recruitment journey includes the following steps:

• Prequalification Interview
• Interview with the Manager
• Interview with Talent Acquisition Team / Human Resources
• Reference Check Process

At one stage of the process, we would be delighted to welcome you to our site to meet in person and share the environment where we work every day to transform patients' lives!

Please note that this recruitment process may be adapted based on the specific requirements of the position.

Our Benefits

• 13th-month salary, contribution to results bonus, profit-sharing / employee participation, and transportation allowance
• 27 days of paid leave, plus 23 RTT days (reduced working hours)
• Flexible remote work options depending on the role
• On-site company restaurant, and a wide range of employee committee (CSE) activities and associations

We are committed to equal opportunities and developing talents in all their diversity. We value both experience and the desire to engage daily in contributing to therapeutic progress for the benefit of patients. If this offer resonates with you, seize this opportunity to meet us!