Postdoctoral Position (M/F) in Synthesis and Bioconjugation

CNRS; France; On-site; EUR 29,000 - 42,000; Full time

Job summary

CNRS, located at the Institut de Chimie Moléculaire de l'Université de Bourgogne, seeks a postdoctoral intern to synthesize bimodal aza-BODIPY-macrocycle probes and characterize them in solution, with a focus on photophysics and bioconjugation to antibodies targeting lymphomas and certain solid tumors. Collaboration with multiple teams and active dissemination of findings are expected.

The role is part of the SMol team within ICMUB (UMR 6302), under the Inserm project on interdisciplinary

Qualifications

• Strong experience in organic synthesis with fluorophores and coordination chemistry.
• Experience in photophysical measurements and data interpretation using spectrofluorimeters.
• Knowledge of bioconjugation techniques.

Responsibilities

• Synthesize bimodal aza-BODIPY-macrocycle probes and characterize them in solution.
• Bioconjugate probes to target antibody and study resulting bioconjugates (DOL, stability, affinity).
• Literature review to identify relevant targets in the field; collaborate with project teams; present results at meetings and conferences.

Skills

Organic synthesis

Fluorophores

Coordination chemistry

Photophysical measurements

Bioconjugation techniques

Teamwork

Autonomy

Tools

NMR

Mass spectrometry

Spectrofluorimeter

Job description

Organisation/Company CNRS Department Institut de Chimie Moléculaire de l'Université de Bourgogne Research Field Mathematics History » History of science Researcher Profile First Stage Researcher (R1) Application Deadline 16 Nov 2026 - 23:59 (UTC) Country France Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Jan 2027 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

As part of an Inserm PCSI project, the postdoctoral intern (M/F) will be responsible for synthesizing bimodal aza-BODIPY-macrocycle probes, characterizing them in solution (particularly in terms of photophysics), and bioconjugating them to an antibody targeting lymphomas and certain solid tumors.

• Conduct a literature review to identify the most relevant target molecules in the field.
• Synthesize bimodal probes and perform their full characterization (NMR, mass spectrometry, photophysical properties, etc.).
• Perform their bioconjugation to the target antibody, followed by studies on the resulting bioconjugates (degree of labeling (DOL), stability, affinity measurements for the targets, etc.).
• Actively collaborate with the other teams involved in the project.
• Attend monthly meetings, present results to the project team, and contribute to the valorization of the findings (writing publications, presenting results at an international conference).

The recruited individual will carry out their missions within the Institute of Molecular Chemistry of the University of Burgundy (ICMUB, UMR 6302, ZRR zone), as part of the SMol team. Their work will be conducted under the Inserm project "Interdisciplinary Approaches to Oncogenic Processes and Therapeutic Perspectives: Contributions of Physics, Chemistry, and Engineering Sciences to Oncology" (BOND: Development of Bimodal Probes based on Wazabys for CD20 targeting and therapy approaches).
The position is located in a sector subject to the Protection of Scientific and Technical Potential (PPST), and therefore, in accordance with regulations, your arrival must be authorized by the competent authority of the Ministry of Higher Education and Research (MESR).

Strong experience in organic synthesis, particularly with fluorophores and coordination chemistry.
Experience in photophysical measurements, including handling a spectrofluorimeter and interpreting data.
Knowledge of bioconjugation techniques.
Soft skills:
Autonomy and self-confidence
Motivation, rigor, and reliability
Strong organizational skills
Intellectual curiosity and critical thinking
Comfortable with teamwork and interactions with colleagues from different participating laboratories.