Postdoc: EV-Based ADME & Liquid Biopsy Scientist

Servier; Gif-sur-Yvette; Hybrid; EUR 70,000 - 95,000; Full time

Benefits offered by this job

13th month salary

Profit-sharing / employeeparticipation

Transportation allowance

27 days paid leave + 23 RTT days

Flexible remote work options depending

On-site company restaurant

Job summary

Servier's R&D Institute at Paris-Saclay seeks a Scientist to optimize liver-derived extracellular vesicle protocols and apply MultiOMICS (proteomics and transcriptomics) to monitor CYP450 and transporter induction/inhibition. You will work with primary hepatocytes and human samples, translating findings into reduced reliance on clinical DDI studies.

You will collaborate across R&D, publish results, and mentor students, contributing to therapeutic progress for patients in a dynamic, global team.

Qualifications

• PhD in biochemistry, molecular biology, cell biology, or equivalent.
• Proven experience with extracellular vesicle extraction and analysis.
• Expertise in sample preparation and core biochemical methods (WB, ELISA, qPCR).
• Experience in proteomics, genomics, and transcriptomics is valued.
• Bioinformatics experience for protein identification and gene expression analysis.
• Knowledge of pharmacokinetics is a plus.
• Ability to mentor internship- or technician-level collaborators.
• Team-oriented, autonomous, and strong communication.

Responsibilities

• Design and conduct experiments with primary human hepatocytes, relevant cell lines, and human samples to set up, test, and optimize liver-derived EV isolation/enrichment protocols
• Evaluate the reliability of EV-based readouts to assess xenobiotic impacts on ADME protein expression (CYP450 and drug transporters induction/inhibition)
• Optimize sample preparation to maximize data yield from minimal plasma volumes
• Perform quantitative studies of global protein and gene expression in extracted EVs and monitor induction effects
• Work transversally with scientists across R&D to execute experiments and generate/analyze proteomics and transcriptomics datasets
• Communicate results internally (presentations/posters) and externally (peer-reviewed journals, posters, conferences), where applicable
• Contribute to general lab activities, including mentoring undergraduate/graduate students and participating in science outreach, where applicable

Skills

Extracellular vesicle extraction

WB/ELISA/qPCR

Proteomics/Genomics/Transcriptomics

Bioinformatics

Pharmacokinetics knowledge

Mentoring

Team collaboration

Scientific communication

Education

PhD in biochemistry, molecular biology, cell biology, or equivalent

Job description

Servier's R&D Institute at Paris-Saclay seeks a Scientist to optimize liver-derived extracellular vesicle protocols and apply MultiOMICS (proteomics and transcriptomics) to monitor CYP450 and transporter induction/inhibition. You will work with primary hepatocytes and human samples, translating findings into reduced reliance on clinical DDI studies.

You will collaborate across R&D, publish results, and mentor students, contributing to therapeutic progress for patients in a dynamic, global team.