Post-doctoral Researcher position on GPCRs and Mitochondria (Paris, 2 years)

European Commission; France; Sur place; EUR 35 000 - 50 000; Plein temps

Résumé du poste

A Paris-based research center is seeking a highly motivated postdoctoral researcher to explore mitochondrial respiration signaling pathways. The position requires a PhD and expertise in biochemistry and cell biology. Applicants should have strong collaborative skills and fluency in English. The role offers a 26-month contract, with a competitive salary based on experience, and starts around November 2025.

Prestations

Renewable contract

Salary according to public service scale

Qualifications

• Solid background in biochemistry, molecular pharmacology, and mitochondrial biology.
• Proven ability to supervise and collaborate in research.
• Experience with data analysis tools.

Responsabilités

• Investigate intra-mitochondrial signaling pathways linked to respiration.
• Plan, execute, and interpret complex experiments.
• Communicate scientific findings effectively.

Connaissances

Biochemistry

Cell Biology

Molecular Pharmacology

Cell Signaling

Fluency in English

Formation

PhD in Biochemistry, Pharmacology, Cell Biology or related disciplines

Outils

CRISPR/Cas9

Western Blot

Microscopy

Description du poste

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Institut Cochin - Functional Pharmacology and Pathophysiology of Membrane Receptors

Organisation/Company Institut Cochin - Functional Pharmacology and Pathophysiology of Membrane Receptors Research Field Biological sciences Researcher Profile Recognised Researcher (R2) Positions Postdoc Positions Country France Application Deadline 13 Oct 2025 - 23:59 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 37 Offer Starting Date 1 Nov 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Your task • We are looking for a highly motivated post-doctoral researcher to investigate intra-mitochondrial signaling pathways linked to mitochondrial respiration (see doi: 10.1016/j.chembiol.2023.07.009. PMID: 37572668) • Main techniques to be performed by the postdoctoral fellow: cell culture (neuronal cell lines and HEK293 cells), western blot, BRET assay, cell signaling, CRISPR/Cas9 in cell lines, mitochondrial respiration analysis, immunoprecipitation experiment coupled MS analysis confocal and high-resolution microscopy

Requirements

For this position, you qualify with a PhD in Biochemistry, Pharmacology, Cell Biology or related disciplines.

• You have a solid background in biochemistry, molecular pharmacology, cell biology and cell signaling

• Specific knowledge on GPCRs, BRET, signal transduction or mitochondrial biology would be an advantage.

• Independently plan, execute, troubleshoot and interpret experiments, experience with data analysis tools

• Supervise a research technician and prepare external research collaborations

• Clearly analyze and communicate scientific findings in written and verbal form

• You have demonstrated the ability to work collaboratively

• Fluency in oral and written English

The Institut Cochin is a research center affiliated to INSERM, CNRS, Université Paris Cité, located in the heart of Paris. It has more than 650 members in 33 research teams, dedicated to high- level biomedical sciences and assisted by 10 cutting-edge core facilities. Ten core facilities provide the scientists of the Institute with the most efficient technological support. Our team is part of the " Metabolism and Endocrinology" department. We have a long-term interest in the involvement of GPCRs in metabolic diseases such as obesity and diabetes and the link to Alzheimer disease. We are an international team composed of about 15 members.

We are offering a 26 months contract, renewable, FRM funded with a salary according to the experience and the scale applicable to the public service. Predicted starting date: Nov 2025 or beginning 2026

Contact

If you are interested to join an international and dynamic team at the Institut Cochin (Paris), please send your application including CV, motivation letter and 2 references to Dr. Ralf Jockers : [e-mail]

Recent references

Br J Pharmacol. 2017. doi: 10.1111/bph.13856; Nature Comm 2018 doi: 10.1038/s41467-018-03609-x; Science Signaling, 2018. doi: 10.1126/scisignal.aan6622; Nat Metab. 2021. doi: 10.1038/s42255-021-00432-5; Cell Mol Life Sci. 2022 doi: 10.1007/s00018-022-04390-3; eLife.2023. doi: 10.7554/eLife.78360; Cell Chem Biol, 2023. doi: 10.1016/j.chembiol.2023.07.009; Nat Metab, 2023. doi: 10.1038/s42255-023-00889-6; Nat Metab 2023 doi: 10.1038/s42255-023-00888-7; JCI Insight, 2024. doi: 10.1172/jci.insight.168418