Post-doctoral position “Intracellular crowding and cellular aging”

Université de Bordeaux; Bordeaux; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

L'Université de Bordeaux propose un projet de recherche permettant d'explorer l'interaction entre biologie, biophysique et génétique au sein d'un environnement stimulant et international. Les candidats travaillant sur la fluidité intracellulaire et le vieillissement des cellules sont particulièrement encouragés à postuler, bénéficiant d'un soutien pour les bourses postdoctorales.

Prestations

50 jours de congés dès la première année

Remboursement de 75% de l'abonnement de transport public

Participation à une couverture santé privée jusqu'à 15€/mois

Activités de loisir, sport et culture pour le personnel

Installations accessibles aux personnes handicapées

Options de stationnement pour le personnel

Package de mobilité durable pour le trajet

Qualifications

• Motivé à travailler à l'interface de la biologie et de la physique.
• Expérience en imagerie cellulaire souhaitée.
• Bonne maîtrise de l'anglais requise.

Responsabilités

• Développer de nouveaux outils d'imagerie et d'analyse.
• Caractériser la biophysique intracellulaire au cours du vieillissement.
• Étudier l'impact de ces propriétés sur la durée de vie chronologique.

Connaissances

Composé de biologie

Biophysique

Imagerie en direct

Formation

Formation en biologie ou biophysique

Description du poste

Today, the Université de Bordeaux is one of the most influential multidisciplinary research universities in France and the world.

Firmly rooted in its core values of education and research, and through its 2030 strategic plan "Making our university model a lever for new balances, actions and impact," the Université de Bordeaux is now stepping up its commitment to the societal challenges of the 21st century, particularly the urgent need to address climate change. As the driving force behind a number of major programs, our ambition is to be an attractive partner, sought after for its capacity to transform in the service of responsible and ethical progress.

Joining us means working in a privileged environment within a particularly diverse and open professional community, benefiting from welcome and inclusion schemes, training and internal mobility. It means taking part in an academic, scientific and human adventure. It's a commitment to meeting the challenges of the 21st century.

The IBGC is a UMR 5095 with 12 research teams and 4 general services (property, management, IT, laundry). The institute also has two microscopy technical platforms: electron microscopy and photonic microscopy.

The IBGC is under the supervision of CNRS Biology and the University of Bordeaux. Its activities are dedicated to fundamental research in biology. The unit is part of the Université de Bordeaux's ecosystem of excellence (Department of Biological and Medical Sciences). It is also part of the Oncosphere regional research network, dedicated to cancer research and supported by the Conseil Régional de Nouvelle Aquitaine.

Cells are self-organized in membrane-enclosed organelles, where energy-driven, active transport events provide spatiotemporal control of cellular processes through the delivery of macromolecules to distinct compartments. In contrast, passive, diffusion-mediated transport was not thought to be regulated. This paradigm was recently challenged when it was discovered that cells also control their diffusional properties. Indeed, budding and fission yeast cells display a remarkable increase in internal stiffness, density and macromolecular crowding when entering quiescence upon glucose starvation. Similar observations were made in bacteria under conditions of low metabolic activity, suggesting that the capacity of cells to modulate their fluidity and the diffusivity of their content may be part of a conserved response to environmental changes.

Interestingly, the capacity of quiescent cells to resume growth diminishes with time. This phenomenon of chronological aging is observed in a broad range of cell types and species, contributing to the long-term behavior of cell populations in both multicellular and unicellular organisms. Our multidisciplinary project uses the fission yeast as a genetic model to investigate the interplay between chronological lifespan and macromolecular crowding. We will focus on:

1. the development of new imaging and analysis tools for monitoring intracellular fluidity
2. the characterization of intracellular biophysics throughout aging
3. how modulating these properties may directly impact chronological lifespan.

We seek candidates motivated to work at the interface of genetics, biology, and physics in an interactive, international environment. This project will be conducted within an interdisciplinary network of collaborators. We welcome applicants with diverse backgrounds, from biology to biophysics. Expertise in live-cell imaging is an advantage. This project is funded by the Frontiers of Life program of the University of Bordeaux. Candidates will receive full support for applying to postdoctoral fellowships and continuing their work beyond the initial period. A good command of English is essential, as the lab and institute operate in English.

More information:

Based in Bordeaux – accessible by tramway line A (stop «Saint Augustin») and buses, bike-friendly.

The laboratory is near the city center of Bordeaux and about 60 km from the Atlantic coast.

Salary gross: €2700 according to the salary grid

Job Benefits:

• 50 days of vacation from the first year
• Reimbursement of 75% of public transport subscription
• Participation in private healthcare up to €15/month
• Leisure, sport, and cultural activities for staff
• Disabled-friendly facilities
• Staff parking options
• Sustainable mobility package for commuting