Post-Doc

Sanofi; Paris; Sur place; EUR 60 000 - 80 000; Plein temps

Résumé du poste

An innovative firm is seeking a Postdoctoral candidate to join a cutting-edge research project focused on gene therapy development. This exciting role involves working with advanced technologies like droplet microfluidic and NGS to analyze single-cell applications. The successful candidate will lead complex experiments, mentor students, and collaborate within a dedicated team. Join a dynamic environment where your contributions will significantly impact the future of gene therapies. If you're passionate about molecular biology and ready to tackle challenging projects, this opportunity is perfect for you.

Qualifications

• Ph.D. in biology or molecular biology required.
• Strong experience in Single-cell RNA sequencing and NGS.

Responsabilités

• Develop and execute complex experiments in molecular biology.
• Mentor students and collaborate with consortium members.

Connaissances

Single-cell RNA sequencing

Molecular biology

NGS experiments

Bioinformatics

Statistical software

Communication skills

Bench work

Formation

Ph.D. in biology or molecular biology

Outils

Prism

Spotfire

NextSeq Illumina

ARIA Fusion (FACS)

Description du poste

time left to apply End Date: June 30, 2025 (30+ days left to apply)

job requisition id R2792417

Post-Doc Position in Sanofi / WIDGET consortium

Expert in Biology, Molecular Biology, NGS & Single Cells

Abstract:

As part of the WIDGeT consortium (23M€, 5 years), we are currently researching a Postdoctoral candidate with a strong background in molecular biology and NGS for single cell application.

Overview of the research project:

The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV’s transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS.

Responsibilities:

1. Develop, design, and execute complex experiments and analyze data.
2. Write (Lab Book) and Present (PowerPoint) research findings.
3. Mentor and co-supervise engineer, technician, and undergraduate students involved in the research project.
4. Report and collaborate with other members of the consortium.

Qualifications :

1. Ph.D. in biology or molecular biology
2. Strong experience in Single-cell RNA sequencing
3. Strong background in molecular biology, NGS experiments and analysis.
4. Background in single cells experiment (10x, flow cytometer...)
5. Appetite for bench work & wet lab
6. Appetite for challenging project
7. Background in Bioinformatics
8. Familiarity with statistical software (Prism, Spotfire, other…)
9. Fluent in English
10. Excellent written and verbal communication skills.
11. Experience with Recombinant AAV is a plus.
12. Knowledge in organoids/tissues preparation is a plus.
13. Experience in screening is a plus.
14. Background in Droplet microfluidic is optional.

The Project Team:

A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer, and one technician.

The Lab:

Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina).

At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity.