Job offer

European Commission; France; Sur place; EUR 30 000 - 40 000; Plein temps

Résumé du poste

Un institut de biologie structurale en France recherche un chercheur pour intégrer le groupe SAGAG. Cette opportunité comprend la caractérisation des complexités enzymatiques de la biosynthèse des glycosaminoglycans, utilisant des méthodes avancées en biologie structurale et biochimie. Le candidat rejoindra une équipe dynamique et internationale au sein d'un environnement stimulant.

Qualifications

• Expérience en biologie structurale ou en biochimie.
• Connaissance des techniques liées à l'analyse cryo-EM.
• Doit travailler au sein d'équipes multiculturelles.

Responsabilités

• Caractériser les complexes enzymatiques impliqués dans la biosynthèse des GAGs.
• Combiner analyses biochimiques avec des approches de biologie structurale.
• Recruté dans le cadre du groupe SAGAG sous la direction de Rebekka Wild.

Connaissances

Biologie structurale

Analyse biochimique

Cryo-EM

Formation

Doctorat en biologie, biochimie ou domaines connexes

Description du poste

Organisation/Company CNRS Department Institut de biologie structurale Research Field Physics Researcher Profile First Stage Researcher (R1) Country France Application Deadline 9 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

Located on the Grenoble Science Park (ESRF/ILL/EMBL/IBS), the Institute of Structural Biology (IBS) is a national and international player in the field of integrated structural biology. The IBS is a research center, a technical platform, a host site and a scientific training center. Its mission is to develop research in structural biology, a field of research that is crucial to the understanding of fundamental biological mechanisms. It is supported by 12 state-of-the-art platforms.
As a joint research unit (CEA-CNRS-UGA), the IBS is composed of 20 research groups, each of which proposes a multi-disciplinary approach, at the frontiers of biology, physics and chemistry, in coherence with 3 research axes. Nearly 320 people work there as researchers, PhD students, engineers and technicians in a multicultural and international environment.
The person recruited will join the team of Rebekka Wild in the 'Structure and Activity of Glycosaminoglycans' (SAGAG) group. The team is interested in understanding the molecular mechanisms of enzymes involved in the biosynthesis of glycosaminoglycans (GAGs). GAGs are long chains of highly complex polysaccharides found on the cell surface, and their biosynthesis involves more than a dozen membrane-bound enzymes localized in the Golgi apparatus. Our team combines in vitro biochemical analyses with structural biology approaches, in particular single-particle cryo-EM, to study the molecular mechanisms of GAG biosynthesis enzymes and their assembly into macromolecular complexes.

Structural characterization of enzyme complexes involved in glycosaminoglycan biosynthesis using single-particle cryo-electron microscopy.