Job offer

European Commission; France; Sur place; EUR 40 000 - 60 000; Plein temps

Résumé du poste

Une université de renoms en France recherche un chercheur en chimie moléculaire pour un doctorat portant sur l'induction de la chiralité dynamique et son utilisation dans des systèmes programmables. Le candidat idéal détient un Master 2 en chimie moléculaire et possède une connaissance approfondie en chimie organique et en spectroscopie RMN. Cela représente une opportunité unique de développer des techniques innovantes pour l’information moléculaire.

Qualifications

• Solide connaissance en chimie générale et chimie organique.
• Expérience en synthèse et caractérisation de ligands et complexes.
• Investissement personnel significatif nécessaire.

Responsabilités

• S'occuper de la synthèse et de la caractérisation des ligands macrocycliques dynamiques.
• Développer des systèmes de chiralité dynamique et les étudier par RMN.

Connaissances

Connaissance générale en chimie

Synthèse organique

Spectroscopie RMN

Aptitude pratique

Formation

Master 2 en chimie moléculaire

Description du poste

Organisation/Company Université de rennes - Institut des Sciences Chimiques de Rennes (ISCR) Research Field Chemistry » Molecular chemistry Researcher Profile First Stage Researcher (R1) Positions PhD Positions Country France Application Deadline 27 Jun 2025 - 12:00 (Europe/Paris) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

General information:the thesis will be carried out in the team Macrocycles Pyrroliques et Processus Bio-Inspirés , under the supervision of Dr. Stéphane Le Gac, at the Institut des Sciences Chimiques de Rennes (UMR CNRS 6226; https://iscr.univ-rennes1.fr/pyrrolic-macrocycles-exotic-coordination-a… ). Period: Oct. 2025-Sept. 2028. Gross salary: ~2300 €/month (financial support from EUR LUMOMAT).

Description:data-storage is undoubtedly a major concern of our modern societies requiring new approaches for information storage and processing. In this context, our group has been investigating for almost a decade various Möbius hexaphyrin architectures for recognition and sensing purposes. Möbius rings are inherently chiral objects (topological chirality),[1] mirror images being generated by twisting the Möbius band according to a right or a left screw sense (respectively P and M configurations). Compared to other sources of chirality, Möbius chirality has been scarcely investigated at the molecular level and thus constitutes an innovative stereogenic element. Focusing on the Möbius [28]hexaphyrin scaffold,[2] our group has investigated an original approach for chirality induction taking advantage of the dynamic character of the twisted π-system.[3] Indeed, this conformationally flexible scaffold undergoes rapid P M equilibrium in solution, thus exhibiting a dynamic Möbius chirality. This feature enables a transfer of chirality from an exogenous stereogenic source under thermodynamic control, useful to build up adaptive or switchable molecular systems.Recently, we have investigated Möbius Zn(II)-hexaphyrins bearing NH2 or COOH chiral coordinating arms, and demonstrated unprecedented chiroptical switches controlled by achiral effectors in complex networked systems.Our idea is now to move one-step further, by merging this dynamic chirality induction with out-of-equilibrium (dissipative) processes. Based on our expertise, this project aims at the development of so-called “time-programmable” Möbius-hexaphyrin winding, so that a chiroptical signature (readout) could be produced with a defined lifetime. Such an approach requires a fuel to trigger chirality induction at the level of the Möbius π-system, which will be cancelled when the fuel is consumed. By tuning the experimental conditions, specific lifetime and decay of the chiroptical readout can be set up, allowing a specific encoding of an information (similarly to Morse code with short and long pulses). These dissipative systems will be investigated by NMR and circular dichroism spectroscopies, with which the lab is well experienced, aiming at defining the best criterion yielding to robust systems.

Where to apply

E-mail [e-mail]

Requirements

Research Field Chemistry » Molecular chemistry Education Level Master Degree or equivalent

Skills/Qualifications

Profile of applicant:t he candidate, with a Master 2 degree in molecular chemistry, must have a solid knowledge in general chemistry and more particularly in organic synthesis and NMR spectroscopy. The synthesis and characterization in solution of dynamic macrocyclic ligands and zinc complexes will constitute an important part of this thesis. A strong practical aptitude as well as a significant personal investment will be necessary. People interested will kindly send a CV, a motivation letter, the contact details of two people who can recommend the candidate as well as their Master’s transcript and diploma.

Research Field Chemistry » Molecular chemistryChemistry » Organic chemistry

Additional Information

Work Location(s)

Number of offers available 1 Company/Institute Institut des Sciences Chimiques de Rennes Country France City Rennes Postal Code 35042 Street 263 avenue du Général Leclerc Geofield