PhD position in multimodal and multiscale biomechanics of the bone-implant interface

TN France; Créteil; Sur place; EUR 30 000 - 60 000; Plein temps

Résumé du poste

An innovative research opportunity awaits you in the field of biomedical engineering, focusing on the intricate relationship between bone tissue and implants. This PhD project aims to unravel the complexities of osseointegration through a blend of experimental and computational methods. You will engage in cutting-edge research that explores the nanostructure of bone and its mechanical properties, contributing significantly to advancements in maxillofacial and orthopedic surgeries. If you are passionate about pushing the boundaries of science and technology in healthcare, this role offers a unique chance to make a lasting impact.

Qualifications

• Strong background in biomechanics and experimental techniques.
• Experience with nanostructure characterization methods.

Responsabilités

• Conduct experiments using animal models and surgical techniques.
• Develop computer models to analyze biomechanical parameters.

Connaissances

Experimental Surgery

Biomechanical Analysis

Nanostructure Characterization

Computer Modeling

Formation

PhD in Biomedical Engineering

Master's in Biomechanics

Outils

FIB-SEM

SAXS

Description du poste

Job Description:

Bone is a living tissue capable of adapting to its environment, such as the insertion of implants, which are widely used in maxillofacial, dental, and orthopedic surgeries. The long-term stability of implants depends on adequate osseointegration, meaning new bone growth around and onto the implant surface. The quality of the interfacial bone tissue and the resulting interface strength are defined by a complex combination of biomechanical properties (structure, composition, mechanics) and a hierarchical structure spanning from the nano- to the macroscale. Despite this, our understanding of how these properties evolve spatially (around the implant) and over time (during healing and remodeling), and how they influence the mechanical resistance of the bone-implant system, remains limited.

This PhD project will employ a coupled experimental and computational approach to investigate how the nanostructure and composition of interfacial bone tissue evolve and influence the mechanical strength of the interface.

Responsibilities:

• Conduct experiments to produce specimens using animal models and experimental surgery.
• Characterize the nanostructure and nanocomposition of the interfacial tissue using advanced techniques (e.g., FIB-SEM, SAXS).
• Develop computer models (e.g., homogenization approach) validated by experimental data to analyze biomechanical parameters across hierarchical scales of bone.