Job offer

European Commission; France; Sur place; EUR 25 000 - 35 000; Plein temps

Résumé du poste

Une institution de recherche renommée en France, au sein du CNRS, propose un poste de chercheur en biologie moléculaire pour étudier les mécanismes de réparation de l'ADN face aux dommages causés par les UV. Le candidat bénéficiera de nombreuses formations techniques et intégrera un projet collaboratif novateur au sein d'un environnement dynamique axé sur l'innovation scientifique.

Qualifications

• Inscription dans l'école doctorale de la santé et des sciences de la vie.
• Connaissance de l'analyse des facteurs génétiques et épigénétiques.
• Formation en communication et rédaction scientifique incluse.

Responsabilités

• Caractériser les facteurs génétiques et épigénétiques influençant la reconnaissance des photolesions.
• Suivre la dynamique des facteurs de dommages photodimensionnels en relation avec différents antécédents génétiques.

Connaissances

Biologie cellulaire

Biologie moléculaire

Génétique

Bioinformatique

Techniques de microscopie

Formation

Diplôme de doctorat en sciences de la vie

Description du poste

Organisation/Company CNRS Department Institut de biologie moléculaire des plantes Research Field Biological sciences » Botany Biological sciences Technology » Biotechnology Researcher Profile First Stage Researcher (R1) Country France Application Deadline 8 Jul 2025 - 23:59 (UTC) Type of Contract Temporary Job Status Full-time Hours Per Week 35 Offer Starting Date 1 Oct 2025 Is the job funded through the EU Research Framework Programme? Not funded by a EU programme Is the Job related to staff position within a Research Infrastructure? No

Offer Description

The position is located at IBMP in Strasbourg (France) and is available for 36 months, starting in October 2025. The Institute of Molecular Biology of Plants (IBMP; http://www.ibmp.cnrs.fr ) is the largest CNRS research institute in plant sciences in France. It hosts 20 research teams and is recognized for its expertise in genomics, genetics, metabolism, biochemistry, cell biology and molecular physiology of plants.

The candidate (M/F) will be enrolled in the Doctoral School of Life and Health Sciences at the University of Strasbourg (http://ed.vie-sante.unistra.fr/ ) which offers numerous technical and cross-disciplinary training courses (108 hours of mandatory training). Within the laboratory, the candidate (M/F) will be supervised by a permanent researcher and a monitoring committee will support them throughout their thesis project.

The candidate (M/F) will join the ANR UVChrom project (UV stress and development: genome-epigenome dynamics in relation to DNA damage capacity and repair mechanisms) involving 3 partners.

Plants use sunlight for photosynthesis and have to cope with the harmful effects of ultraviolet (UV). UV induces DNA lesions (photolesions) which modify the conformation of the DNA and interfere with DNA replication and transcription. Photolesions are repaired by 2 main pathways: Direct Repair (DR) and Nucleotide Excision Repair (NER). DR is a light-dependent repair mechanism involving photolyases that reverse DNA damage. NER is independent of light and involves the excision of photolesions and the synthesis of a new strand of DNA free from any damage. The research team demonstrated that the orientation of repair by one or the other pathway depends on the level of chromatin compaction and therefore on the epigenetic context of the UV-damaged regions. The objective of the project is to characterize the loading dynamics on the chromatin of different factors involved in DR and/or in NER depending on the epigenetic context.

The project will focus on two axes:

The first axis will aim to characterize/ identify genetic and epigenetic factors that influence the dynamics of photodamage recognition factors. For this the association/dissociation with chromatin will be followed in different genetic backgrounds presenting alterations of the epigenome.

The second axis will aim to characterize genomic regions (i) where photodamage recognition factors are present (ii) enriched in photolesions. The combination of these different approaches will allow characterizing the genetic and epigenetic determinants involved in the formation and recognition of UV-induced DNA damage.

This project offers knowledge and experience in cell biology, molecular biology, genetics, and bioinformatics. The candidate (M/F) will learn techniques in chromatin biochemistry, microscopy, and functional genomics. The candidate (M/F) will also be trained in writing and communication skills, as well as in presenting results to different audiences.